Preparation of drug-immobilized anti-adhesion agent using visible light-curable alginate derivative containing furfuryl group

Noh, Seung-Hyun; Kim, Shin-Woong; Kim, Jae-Won; Lee, Tae‐Hoon; Nah, Jae‐Woon; Lee, Young-Gi; Kim, Mi-Kyung; Ito, Yoshihiro; Son, Tae‐Il

doi:10.1016/j.ijbiomac.2018.09.195

Cited by 14 publications

(10 citation statements)

References 31 publications

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“…Another important reason for CSEM to prevent adhesions is to promote wound healing and reduce inflammation. 61 In the process of wound healing, bleeding and wound infection slow wound healing. Therefore, biomaterials with antibacterial and hemostatic properties are required for wound repair.…”

Section: Discussionmentioning

confidence: 99%

A nano chitosan membrane barrier prepared via Nanospider technology with non-toxic solvent for peritoneal adhesions’ prevention

Zhang

Wen

et al. 2021

J Biomater Appl

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Peritoneal adhesion is one of the most common postsurgical complications and can cause bowel obstruction, pelvic pain, and infertility. Setting up a physical barrier directly between the injured site and surrounding tissues is an effective solution for preventing this adverse situation. This study investigated a chitosan electrospun membrane (CSEM) as a potent anti-adhesion barrier, which was prepared by a needleless technology called Nanospider. Scanning electron microscopy revealed that CSEM is a laminated nanofiber with good mechanical properties. The fiber is uniform with the diameter distributing in the range of 100–120 nm. The tensile strength can reach 27.45 ± 6.30 MPa with a maximum elongation at break of 18.50 ± 1.44%, which makes it stick easily to damaged parts but not to be easily damaged by tissue friction. The growth of S. aureus on CSEM was 59.18% lower than the control at 10 h, which indicates its better antibacterial property. In addition, CSEM has good coagulant and biocompatibility characteristics. It can perform hemostatic function within 10 min and the L929 mouse fibroblast viability on it was 92.18% ± 1.08% on the seventh day. In vivo experiments indicated that CSEM significantly prevented peritoneal adhesions within four weeks after surgery with wound surface coverage. These results indicate that CSEM is a promising anti-adhesion barrier material.

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Section: Discussionmentioning

confidence: 99%

A nano chitosan membrane barrier prepared via Nanospider technology with non-toxic solvent for peritoneal adhesions’ prevention

Zhang

Wen

et al. 2021

J Biomater Appl

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Section: Photoinitiatorsmentioning

confidence: 99%

“…Riboflavin (vitamin B2) is one of the natural photoinitiators proved to be nontoxic, biodegradable, and biocompatible. Recent studies showed its efficiency in visible light curable furfuryl-alginate derivative 43 or upon exposure to dental curing light of collagenous biomaterials. 44,45 The presence of free radicals is potentially toxic to living tissues; therefore, some photoinitiator-free photo-cross-linkable systems were documented in the literature.…”

Section: Photoinitiatorsmentioning

confidence: 99%

“…61 Alginate was also used to create biomaterials with the opposite effect, of anti-adhesiveness, as reported by several authors. 43,62,63 In this regard, alginate was coupled with furfurylamine and further gelation took place in the presence of Rose Bengal or riboflavin, under visible light. The curing systems can serve for the immobilization of epidermal growth factor 62 or for fluorescein isothiocyanate−bovine serum albumin as model drug.…”

Section: Photoinitiatorsmentioning

confidence: 99%

“…The curing systems can serve for the immobilization of epidermal growth factor 62 or for fluorescein isothiocyanate−bovine serum albumin as model drug. 43 Immobilization of the epidermal growth factor promotes cell growth, proliferation, and differentiation and facilitates wound healing. 62 The application of alginate as a physical barrier fits with its natural poor cell adhesion and film forming capacity.…”

Section: Photoinitiatorsmentioning

confidence: 99%

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Photopolymerization of Bio-Based Polymers in a Biomedical Engineering Perspective

Chiulan

Heggset²,

Voicu

et al. 2021

Biomacromolecules

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Photopolymerization is an effective method to covalently cross-link polymer chains that can be shaped into several biomedical products and devices. Additionally, polymerization reaction may induce a fluid–solid phase transformation under physiological conditions and is ideal for in vivo cross-linking of injectable polymers. The photoinitiator is a key ingredient able to absorb the energy at a specific light wavelength and create radicals that convert the liquid monomer solution into polymers. The combination of photopolymerizable polymers, containing appropriate photoinitiators, and effective curing based on dedicated light sources offers the possibility to implement photopolymerization technology in 3D bioprinting systems. Hence, cell-laden structures with high cell viability and proliferation, high accuracy in production, and good control of scaffold geometry can be biofabricated. In this review, we provide an overview of photopolymerization technology, focusing our efforts on natural polymers, the chemistry involved, and their combination with appropriate photoinitiators to be used within 3D bioprinting and manufacturing of biomedical devices. The reviewed articles showed the impact of different factors that influence the success of the photopolymerization process and the final properties of the cross-linked materials.

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Sustainable biomedical microfibers from natural products

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Cao,

Luo

et al. 2024

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Microfibers from natural products are endowed with remarkable biocompatibility, biodegradability, sustainable utilization as well as environmental protection characteristics etc. Benefitting from these advantages, microfibers have demonstrated their prominent values in biomedical applications. This review comprehensively summarizes the relevant research progress of sustainable microfibers from natural products and their biomedical applications. To begin, common natural elements are introduced for the microfiber fabrication. After that, the focus is on the specific fabrication technology and process. Subsequently, biomedical applications of sustainable microfibers are discussed in detail. Last but not least, the main challenges during the development process are summarized, followed by a vision for future development opportunities.

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Preparation of drug-immobilized anti-adhesion agent using visible light-curable alginate derivative containing furfuryl group

Cited by 14 publications

References 31 publications

A nano chitosan membrane barrier prepared via Nanospider technology with non-toxic solvent for peritoneal adhesions’ prevention

A nano chitosan membrane barrier prepared via Nanospider technology with non-toxic solvent for peritoneal adhesions’ prevention

Photopolymerization of Bio-Based Polymers in a Biomedical Engineering Perspective

Sustainable biomedical microfibers from natural products

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