Preparation of drug-loaded nanofiber membrane / PLA core-coated absorbable surgical suture and its controllable drug release performance

Abstract

Polylactic acid (PLA) surgical suture is considered to be one of the most ideal materials for tissue closure due to its rich raw materials and excellent biological properties. However, surgical sutures face great challenges due to problems such as wound infection and tissue reaction in practical applications. In order to improve the clinical applicability of surgical sutures, we constructed a new drug-loading system for core-spun surgical sutures. The shell was composed of nanofibrous membranes composed of polyglycolic acid (PGA) and polycaprolactone (PCL) and ciprofloxacin (CIP) antibacterial drugs, the core layer adopts PLA filament. By adjusting the composition ratio of polyglycolic acid and polycaprolactone in the shell, a new mode of regulating the release rate and release cycle of the suture was constructed. According to different wound healing time, different drug release cycles of surgical suture were selected. In the study, the higher the shell PGA content and drug loading, the faster the drug release rate. When the carrier ratio polyglycolic acid / Polycaprolactone was 80 / 20 and the drug loading was 3%, the drug release rate was the fastest and the drug release was high. The successful preparation of core-spun yarn surgical suture provides a new idea for the study of new antibacterial surgical suture.