Preparation of environmental-responsive chitosan-based nanoparticles by self-assembly method

Chuang, Chung-Yang; Don, Trong‐Ming; Chiu, Wen‐Yen

doi:10.1016/j.carbpol.2010.01.053

Cited by 21 publications

(9 citation statements)

References 33 publications

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“…As reported, CTS could be degraded by strong acid such as hydrochloric acid into small molecules (Chuang et al, 2010). So in this study, CTS-g-PNIPAAm grafted copolymers were first processed with hydrochloric acid to obtain a series of linear PNIPAAm polymers.…”

Section: The Mw Of Pnipaam Chainsmentioning

confidence: 99%

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Investigation of dual-sensitive nanogels based on chitosan andN-isopropylacrylamide and its intelligent drug delivery of 10-hydroxycamptothecine

Wang

et al. 2014

Drug Delivery

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The work was to prepare and characterize a responsive drug delivery system built of chitosan-g-poly (N-isopropylacrylamide) (CTS-g-PNIPAAm) nanogels and to evaluate the effects of CTS molecular weight (Mw) on the loading and in vitro release of insoluble drug 10-hydroxycamptothecine (HCPT). The CTS-g-PNIPAAm copolymers were synthesized by radical polymerization. The Mw and physical chemistry properties such as diameter, second virial coefficient of grafted PNIPAAm were investigated by dynamic and static laser light scattering method. A series of cross-linked CTS-g-PNIPAAm nanogels were prepared with N, N'-methylenebisacrylamide initially added as a cross-linker. The thermal and pH-sensitive features of cross-linked CTS-g-PNIPAAm nanogels were studied by determining the variance of transmittance, changeable size and reversed zeta potential. The critical aggregation concentrations (CAC) of resultant nanogels decreased from 0.045 to 0.036 mg/mL with CTS Mw increased from 50 kDa to 700 kDa. The loading efficiency of the HCPT encapsulated into CTS-g-PNIPAAm nanogels increased in parallel with CTS Mw, while the cumulative release percentage of HCPT-loaded nanogels decreased with CTS Mw increasing at both 25 °C and 37 °C. Fitting results of HCPT release data to different mathematical models suggested a diffusion-controlled mechanism at 25 °C. However, the release behaviors were dominated by combined effects of polymer erosion and osmotic pressure driven at 37 °C. The cytotoxicity study of the CTS-g-PNIPAAm nanogels against hepatic L02 cells indicated that the resultant nanogels did not exhibit apparent cytotoxicity.

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Section: The Mw Of Pnipaam Chainsmentioning

confidence: 99%

“…A series of CTS-g-PNIPAAm copolymers were hydrolyzed by 12 M HCl(aq) for 4 h at 40 C to degrade the CTS chain and obtain PNIPAAm (Chuang et al, 2010). Before the SLLS, the increscent of the refractive index dn/dCp of PNIPAAm was determined by the double bean differential refraction meter firstly as about 0.171 mL/g.…”

Section: The Determination Of Mw Of Pnipaammentioning

confidence: 99%

Investigation of dual-sensitive nanogels based on chitosan andN-isopropylacrylamide and its intelligent drug delivery of 10-hydroxycamptothecine

Wang

et al. 2014

Drug Delivery

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“…Chitosan-based nanoparticles designed for encapsulation of hydrophilic drugs were prepared by Chuang et al [19], by grafting chitosan with poly(N-isopropyl acrylamide) (PNIPAM), a well-known temperature-responsive polymer [72,73] used in DDSs [74][75][76]. The graft copolymer was obtained by polymerizing N-isopropyl acrylamide in the presence of chitosan.…”

Section: Temperature-responsive Chitosan Nanoparticlesmentioning

confidence: 99%

“…Ionic complexes are attractive for their simplicity and because their selfassembly is responsive to pH and ionic strength. Polysaccharide DDSs can be made responsive to other stimuli, including heat, magnetism, and light [18][19][20][21][22][23]. In many cases, this response to environmental change is often reversible, thus, a "switching" effect can be built into the polymer nanostructure that will respond to stimulation in vivo.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled polysaccharide nanostructures for controlled-release applications

Myrick

Vendra

Krishnan

2014

Nanotechnology Reviews

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Self-assembling polysaccharide nanostructures have moved to the forefront of many fields due to their wide range of functional properties and unique advantages, including biocompatability and stimulus responsiveness. In particular, the field of controlled release, which involves influencing the location, concentration, and efficacy of active pharmaceutical ingredients (APIs), diagnostics, nutrients, or other bioactive compounds, has benefited from polysaccharide biomaterials. Nanostructure formation, stimulus responsiveness, and controlledrelease performance can be engineered through facile chemical functionalization and noncovalent intermolecular interactions. This review discusses polysaccharide nanoparticles, designed for targeted and time-controlled delivery of emerging APIs, with improved in vivo retention, stability, solubility, and permeability characteristics. Topics covered include nanoparticles of cyclodextrin and cyclodextrin-containing polymers, hydrophobically modified polysaccharides, polysaccharide nanoparticles that respond to pH, temperature, or light stimulus, polysaccharide prodrug complexes, polysaccharide complexes with lipids and proteins, and other polysaccharide polyelectrolyte complexes.

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“…5 Chitosan-g-poly(N-isopropylacrylamide) [CTS-poly(NIPAA m)] nanogel was reported as a potential antitumor drug carrier that could respond to temperature and pH simultaneously. [6][7][8][9] Optimal conditions including molecular weight (Mw) of chitosan (CTS), Mw of grafted PNIPAAm, and reaction conditions were fully investigated in our former studies. 10 However, the clinical use was further limited by the low volume phase transition temperature (VPTT) appeared at 32 • C-33 • C. For decades, many researchers dedicated much time to regulate VPTT by adding hydrophilic and hydrophobic molecules, such as acrylic acid, 11 cucurbit [8] uril-viologen, 12 acrylamide (AAm), 13 and so on to meet specific needs.…”

Section: Introductionmentioning

confidence: 99%

Development of a Thermally Responsive Nanogel Based on Chitosan–Poly(N-Isopropylacrylamide- co -Acrylamide) for Paclitaxel Delivery

Wang

et al. 2014

Journal of Pharmaceutical Sciences

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Preparation of environmental-responsive chitosan-based nanoparticles by self-assembly method

Cited by 21 publications

References 33 publications

Investigation of dual-sensitive nanogels based on chitosan andN-isopropylacrylamide and its intelligent drug delivery of 10-hydroxycamptothecine

Investigation of dual-sensitive nanogels based on chitosan andN-isopropylacrylamide and its intelligent drug delivery of 10-hydroxycamptothecine

Self-assembled polysaccharide nanostructures for controlled-release applications

Development of a Thermally Responsive Nanogel Based on Chitosan–Poly(N-Isopropylacrylamide- co -Acrylamide) for Paclitaxel Delivery

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