Preparation of eugenol nanoemulsions for antibacterial activities

Fu, Xuan; Gao, Yuan; Yan, Wei; Zhang, Ziluo; Sarker, Shovra; Yin, Yinyan; Liu, Qi; Feng, Jianguo; Chen, Jing

doi:10.1039/d1ra08184e

Cited by 41 publications

(19 citation statements)

References 53 publications

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“…A reduction in particle MDD with increasing OSR from 1:0.5 to 1:1 (199–154.94 and 134.5–115.9 nm for bath‐ and probe‐sonicated NEs, respectively), could be attributed to increased disruption force and decreased recoalescence force. The lower interfacial tension at the oil/water interface resulted in a highly dynamic interface that facilitated small droplet formation (Ghosh et al ., 2013; Fu et al ., 2022). However, the MDD was found to increase from 1:1 to 1:3 OSR (154.94–220.4 and 115.9–132.7 nm for bath‐ and probe‐sonicated NEs, respectively).…”

Section: Resultsmentioning

confidence: 99%

Grapefruit peel essential oil nanoemulsions: preparation, characterisation, stability and antifungal potential against Penicillium digitatum of Kinnow

Dudeja

Tandon

Kalia

2023

Int J of Food Sci Tech

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Summary Hydrophobicity of essential oils poses a big hindrance for harnessing their diverse antimicrobial portfolio. The study was therefore planned to develop and explore grapefruit peel essential oil nanoemulsions (GPEO‐NEs) as an eco‐friendly hydrophilic alternate against Penicillium digitatum, a prominent postharvest fungus of kinnow. GPEO‐NEs were prepared by mixing GPEO and surfactant (Tween 80) in different ratios (v/v) viz 1:0.5–1:3 by bath and probe sonication. The 1:1 OSR GPEO‐NE (20 min) by probe sonication exhibited consistent droplet diameter (96.6 nm) and PDI (0.247). All GPEO‐NEs were evaluated for antifungal potential against P. digitatum using poisoned food technique. The GPEO‐NEs (1:1 OSR; 20 min) revealed the best efficacy (88.6%) as compared to pure GPEO (76.6%). Optical microscopy further revealed stronger suppressive activity of GPEO‐NEs for spore germination and hyphal distortion of P. digitatum than pure oil. The GPEO‐NEs can thus serve as a green alternative to synthetic fungicides for managing postharvest losses in kinnow by using these as coatings.

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Section: Resultsmentioning

confidence: 99%

Grapefruit peel essential oil nanoemulsions: preparation, characterisation, stability and antifungal potential against Penicillium digitatum of Kinnow

Dudeja

Tandon

Kalia

2023

Int J of Food Sci Tech

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“…ROS attacks the unsaturated fatty acids in cell membrane to form lipid peroxidation products, such as malondialdehyde, changing the fluidity and permeability of cell membrane. [69] Hong et al found that copper alloy-mediated E. coli death was mainly mediated by membrane lipid peroxidation. [70] Copper ion (Cu 2+ ) participate in the Fenton-like reaction to generate ROS.…”

Section: Interference Of Behaviors and Functionsmentioning

confidence: 99%

Flourishing Antibacterial Strategies for Osteomyelitis Therapy

et al. 2023

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Osteomyelitis is a destructive disease of bone tissue caused by infection with pathogenic microorganisms. Because of the complex and long-term abnormal conditions, osteomyelitis is one of the refractory diseases in orthopedics. Currently, anti-infective therapy is the primary modality for osteomyelitis therapy in addition to thorough surgical debridement. However, bacterial resistance has gradually reduced the benefits of traditional antibiotics, and the development of advanced antibacterial agents has received growing attention. This review introduces the main targets of antibacterial agents for treating osteomyelitis, including bacterial cell wall, cell membrane, intracellular macromolecules, and bacterial energy metabolism, focuses on their mechanisms, and predicts prospects for clinical applications.

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“…The preparation of usAgNPs-PL/CMC hydrogel First, whole blood was taken from the cardiac apex of rats, centrifuged at 3000 rpm for 20 min, then the upper layer was taken to obtain PL according to the previous report [22]. 0.5 g of usAgNPs was added to 10 ml of DMSO under ultrasonation for 45 min followed by the mixing with 10ml of PL.…”

Section: Cell Culturementioning

confidence: 99%

“…The centrifuge tube cover was heated at 95 ℃ for 40 min, cooled, then the samples were centrifuged at 12000r/min for 2 min, At last the absorbance value was determined at 532 nm. MDA content in bacterial cells were calculated according the report [22] .…”

Section: Detection Of Bacterial Intracellular Atpmentioning

confidence: 99%

Multifunctional hydrogel containing platelet camouflaged ultra-small silver nanoparticles accelerates diabetic wound healing in Type 1 Diabetic rats

Wang

Geng

Liu

et al. 2023

Preprint

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Bacterial infection and impaired angiogenes are always great obstacles in the wound healing of diabetes. A diabetic wound causes thousands of infections or deaths around the world each year, so the problem of multidrug-resistant (MDR) cannot be ignored. Here, we synthesized a new ultra-small silver nanoparticles (usAgNPs) and conjugated usAgNPs with platelets (usAgNPs-PL) and loaded into CMC hydrogel (usAgNPs-PL/CMC hydrogel), and treated diabetic wound healing in streptozotocin-induced diabetic rat models. The usAgNPs-PL/CMC hydrogel was characterized by SEM, TEM and XPS spectra. The antibacterial ability was detected by XTT dyeing, ROS, bacterial biofilm assay, bacterial activity, et al. The results showed that usAgNPs had smaller particle size (13 nm) than traditional silver nanoparticles and evenly distributed. The Ag + released from usAgNPs can kill bacteria by interfering with bacterial intracellular metabolism; generation of ROS; damaging cell membrane integrity and inhibiting biofilm formation. And combined platelets were enhancing the angiogenesis of endothelial cells by regulating VEGF, PI3K-AKT. Together, this work describes the first example of constructing an all-in-one CMC hydrogel for antimicrobial diabetes wound treatment and showcases the promise of combined antimicrobials and angiogenesis achieved by using the CMC hydrogel in biomedicine applications.

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Preparation of eugenol nanoemulsions for antibacterial activities

Abstract: We developed a novel eugenol nanoemulsion with high stability and good biological activity, which may provide a promising and effective method for wound treatment in the healthcare area.

Cited by 41 publications

References 53 publications

Grapefruit peel essential oil nanoemulsions: preparation, characterisation, stability and antifungal potential against Penicillium digitatum of Kinnow

Grapefruit peel essential oil nanoemulsions: preparation, characterisation, stability and antifungal potential against Penicillium digitatum of Kinnow

Flourishing Antibacterial Strategies for Osteomyelitis Therapy

Multifunctional hydrogel containing platelet camouflaged ultra-small silver nanoparticles accelerates diabetic wound healing in Type 1 Diabetic rats

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