1979
DOI: 10.1046/j.1537-2995.1979.19580059817.x
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Preparation of Factor VIII Concentrates by Cryoprecipitate Sedimentation

Abstract: A new method for factor VIII concentrate preparation is proposed. The method is the collection of cryoprecipitate after sedimentation at 4 C in a jacketed glass vessel. The final product is standardized (4.0 +/- 0.3 factor VIII units per ml) and can be infused in hemophilic patients regardless of their ABO blood type. Factor VIII recovery (52.2 +/- 6.4%) is comparable to other processes.

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Cited by 3 publications
(2 citation statements)
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“…To comply with purity specifications of these therapeutic products (purity greater than 96%),47 both albumin and IgG rich solutions should be further purified, for example, by additional chromatography or through process optimization. Moreover, it is important to evaluate the recovery of other therapeutic proteins present in plasma such as coagulation factors, obtained from cryoprecipitate48, 49 and cryo‐poor plasma 2. Proteomic analysis of the proteins present in both phases can elucidate the partition of other proteins of therapeutic value in the ATPS.…”
Section: Discussionmentioning
confidence: 99%
“…To comply with purity specifications of these therapeutic products (purity greater than 96%),47 both albumin and IgG rich solutions should be further purified, for example, by additional chromatography or through process optimization. Moreover, it is important to evaluate the recovery of other therapeutic proteins present in plasma such as coagulation factors, obtained from cryoprecipitate48, 49 and cryo‐poor plasma 2. Proteomic analysis of the proteins present in both phases can elucidate the partition of other proteins of therapeutic value in the ATPS.…”
Section: Discussionmentioning
confidence: 99%
“…Since the use of cryoprecipitate represented an enormous leap forward in therapy at that time [29], a variety of approaches were evaluated for improvement of the technique [30][31][32][33][34][35][36][37]. In an attempt to improve the potency of cryoprecipate, donor ' stimulation ' with DDAVP (1-deamino-8-D-argininine or desmopressin) was used [38,39].…”
mentioning
confidence: 99%