Preparation of Fe3O4@SiO2@Tannic acid double core-shell magnetic nanoparticles via the Ugi multicomponent reaction strategy as a pH-responsive co-delivery of doxorubicin and methotrexate

Javanbakht, Siamak; Shadi, Mehrdad; Mohammadian, Reza; Shaabani, Ahmad; Ghorbani, Marjan; Rabiee, Ghazal; Amini, Mostafa M.

doi:10.1016/j.matchemphys.2020.122857

Cited by 52 publications

(15 citation statements)

References 49 publications

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“…TA microgels were also reported for their capability of selectivity and sensitivity in targeted drug release studied [ 24 , 25 ]. As regulating drug release is important and TA has inherently possessed some medicinal properties and can specifically interact with vast range of molecules and metal ion, the design and utilization of TA microgels as advance, amendable, and long-lasting drug delivery system is reasonable [ 26 , 27 ]. Furthermore, to treat a damaged tissue or cells in wound healing applications, TA films were shown successful in aiding to heal the wounds or damaged cells [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Self-Crosslinked Ellipsoidal Poly(Tannic Acid) Particles for Bio-Medical Applications

Şahiner

2021

Molecules

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Self-crosslinking of Tannic acid (TA) was accomplished to obtain poly(tannic acid) (p(TA)) particles in single step, surfactant free media using sodium periodate (NaIO4) as an oxidizing agent. Almost monodisperse p(TA) particles with 981 ± 76 nm sizes and −22 ± 4 mV zeta potential value with ellipsoidal shape was obtained. Only slight degradation of p(TA) particles with 6.8 ± 0.2% was observed at pH 7.4 in PBS up to 15 days because of the irreversible covalent formation between TA units, suggesting that hydrolytic degradation is independent from the used amounts of oxidation agents. p(TA) particles were found to be non-hemolytic up to 0.5 mg/mL concentration and found not to affect blood clotting mechanism up to 2 mg/mL concentration. Antioxidant activity of p(TA) particles was investigated by total phenol content (TPC), ferric reducing antioxidant potential (FRAP), trolox equivalent antioxidant capacity (TEAC), total flavanoid content (TFC), and Fe (II) chelating activity. p(TA) particles showed strong antioxidant capability in comparison to TA molecules, except FRAP assay. The antibacterial activity of p(TA) particles was investigated by micro-dilution technique on E. coli as Gram‑negative and S. aureus as Gram-positive bacteria and found that p(TA) particles are more effective on S. aureus with over 50% inhibition at 20 mg/mL concentration attained.

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Section: Introductionmentioning

confidence: 99%

Self-Crosslinked Ellipsoidal Poly(Tannic Acid) Particles for Bio-Medical Applications

Şahiner

2021

Molecules

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“… 18 The absorption peak at 1340 cm −1 is caused by C–N stretching, which is due to the oxidation of HNO 3 . 32 For BC-NH2, the absorption peak at 1606 cm −1 is caused by the N–H group of the cross-linking reaction, and the absorption peak at 1539 cm −1 is caused by the bending vibration of the N–H bond in the amide group. 36 The absorption peak at 899 cm −1 is caused by the stretching vibration of the C–H bond.…”

Section: Resultsmentioning

confidence: 99%

“… 31 Siamak Javanbakht et al prepared dual-core shell magnetic nanoparticles through the Ugi reaction to improve drug release and enhance resistance to cancer cells. 32 Zhenghua Li et al used Pd to catalyze the Ugi reaction, and the cyclization method can be controlled by selecting an appropriate ligand to obtain different types of products in high yields. 33 However, there are few reports on the removal of heavy metals by preparing adsorbents via multicomponent reactions.…”

Section: Introductionmentioning

confidence: 99%

Removal of copper ions by functionalized biochar based on a multicomponent Ugi reaction

2021

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“…Multi‐component reactions (MCRs) involving the use of three substrates that react together in a short reaction time and economic reaction conditions [ 36,37 ] . Specific products might be produced through MCRs reactions, which is the main aim of such reactions [ 38,39 ] .…”

Section: Resultsmentioning

confidence: 99%

Uses of ethyl benzoyl acetate for the synthesis of thiophene, pyran, and pyridine derivatives with antitumor activities

Ibrahim

Mohareb

2020

Journal of Heterocyclic Chem

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The N‐(arly)propanamide derivatives 3a,b were used for a series of heterocyclization reactions to give thiophene, pyran, and pyridine derivatives. Thus, these compounds underwent the Gewald's thiophene synthesis through their reactions with either malononitrile or ethyl cyanoacetate and elemental sulfur to afford compounds 6a‐f, respectively. In addition, they were subjected through a series of multicomponent reactions (MCRs) to give pyran and fused derivatives. The reactions of 3a,b with either malononitrile or ethyl cyanoacetate gave pyridine derivatives 14a‐d, respectively. The latter compounds afforded arylhydrazone derivatives 15a‐m through their reactions with any of the aromatic diazonium salts 15a‐c. The antitumor of the synthesized compounds against A549 (nonsmall cell lung cancer), H460 (human lung cancer), HT‐29 (human colon cancer), and MKN‐45 (human gastric cancer cancer) cancer cell lines together with foretinib as the positive control by a MTT assay was measured, and the results obtained showed that many compounds exhibited high potency against the six cancer cell lines.

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Preparation of Fe3O4@SiO2@Tannic acid double core-shell magnetic nanoparticles via the Ugi multicomponent reaction strategy as a pH-responsive co-delivery of doxorubicin and methotrexate

Cited by 52 publications

References 49 publications

Self-Crosslinked Ellipsoidal Poly(Tannic Acid) Particles for Bio-Medical Applications

Self-Crosslinked Ellipsoidal Poly(Tannic Acid) Particles for Bio-Medical Applications

Removal of copper ions by functionalized biochar based on a multicomponent Ugi reaction

Uses of ethyl benzoyl acetate for the synthesis of thiophene, pyran, and pyridine derivatives with antitumor activities

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