This study was conducted to examine the antioxidant activity of the ferments from Scutellaria baicalensis extracts by lactic acid bacteria to confirm the possibility for the development of functional sources. After the production of Scutellaria baicalensis extract, fermentation was carried out for 3 days through 3 Lactobacillus (Lactobacillus paracasei, Lactobacillus plantarum, Leuconostoc mesenteroides) to finally prepare 3 fermentation extracts. During the fermentation period, pH decreased, and the total polyphenol content was significantly higher at 38.57±0.87 mg GAE/g of the fermented Scutellaria baicalensis extract of Lactobacillus paracasei, and the total flavonoid content was also significantly higher at 33.21±5.62 mg CE/g in the fermented Scutellaria baicalensis extract of Lactobacillus paracasei. In the case of DPPH radical scavenging ability, the Lactobacillus paracasei fermented Scutellaria baicalensis extract was significantly higher at 67.83±0.41%. Therefore, this study shows the possibility that the fermentation of the Scutellaria baicalensis extract can be used as a functional material of a functional sauce.