Preparation of functional and reactive nanosilver nanogels using oxidized carboxymethyl cellulose

Somani, Manali; Mukhopadhyay, Samrat; Gupta, Bhuvanesh

doi:10.1016/j.ijbiomac.2023.123515

Cited by 10 publications

(7 citation statements)

References 42 publications

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“…Bacterial adhesion on the surface was assessed using SEM. The change in bacterial cells was observed using transmission electron microscopy (TEM). , Different samples were immersed in a bacterial suspension of 10 5 –10 6 CFU/mL for 24 h at 37 °C. Subsequently, 1 mL from the suspension was collected and centrifuged further.…”

Section: Methodsmentioning

confidence: 99%

“…Biofilms developed on biomaterial implant surfaces are difficult to eradicate with antibiotics, requiring surgical debridement and reoperation in the worst scenario. These complications result in increased healthcare costs for patients along with increasing infection rates. , …”

Section: Introductionmentioning

confidence: 99%

“…These complications result in increased healthcare costs for patients along with increasing infection rates. 4,5 Thermoplastic polyurethanes (PU) are good candidates for designing biomaterial implants due to their tunable physicochemical properties, biocompatibility, biodegradability, and physical properties that mimic the properties of natural tissues. 6 However, biofilms are readily formed on the PU implant surface when planktonic bacteria are adsorbed and proliferate further.…”

Section: Introductionmentioning

confidence: 99%

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Amination of Polyurethane for Designing Infection-Resistant Surfaces

Somani,

Mukhopadhyay,

Gupta

2023

Ind. Eng. Chem. Res.

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Polyurethane (PU) has emerged as a promising class of polymeric material for biomedical applications due to its outstanding physicochemical properties. However, the resulting immune response and on-site infections are unavoidable consequences of PU-based implants. Immobilizing bioactive agents and biopolymers is an excellent approach to overcome these issues. However, the inherent inertness and hydrophobicity of PU create restraint on the immobilization of bioactive agents on its surface. In this work, a PU film was subjected to aminolysis using ethylene diamine (EDA) under varied temperatures, time, and EDA concentrations. The influence of reaction parameters on the formation of free amino (−NH 2 ) groups and the resulting changes in the physicochemical properties of PU were investigated further. The optimized amine content was ∼0.08 μM/cm 2 after treatment with 10% EDA for 15 min. The surface was characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), and contact angle measurement. Ciprofloxacin was used as a prototype drug and was immobilized by the dip-coating approach on the functionalized PU surface. The drug-immobilized PU showed excellent antibacterial and antibiofouling efficacy against both Gram-positive and Gram-negative bacteria.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Amination of Polyurethane for Designing Infection-Resistant Surfaces

Somani,

Mukhopadhyay,

Gupta

2023

Ind. Eng. Chem. Res.

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“…It is mainly the surface modification of polymers that plays an essential role in modern technological advancements, especially when it comes to materials used in various biomedical applications. [4][5][6] Such modifications impart superficial functionalities to polymeric materials up to nanoscale levels without affecting their bulk properties. 7 Plasma is recognized as an efficient, eco-friendly and costeffective surface treatment process for polymeric materials.…”

Section: Introductionmentioning

confidence: 99%

“…The requirement for developing ideal biomaterials involves structures with controlled physical, chemical and biological properties. It is mainly the surface modification of polymers that plays an essential role in modern technological advancements, especially when it comes to materials used in various biomedical applications 4–6 . Such modifications impart superficial functionalities to polymeric materials up to nanoscale levels without affecting their bulk properties 7 …”

Section: Introductionmentioning

confidence: 99%

Functional surfaces by plasma grafting of itaconic acid onto polypropylene mesh: synthesis and structural investigations

Sethi,

Verma,

Mukhopadhyay

et al. 2023

Polymer International

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Polypropylene (PP) is an unflinching element of biomaterials for human healthcare, leading to enormous possibilities for their functional development within a broad range of biocompatible and bioreceptive materials. Plasma grafting of itaconic acid was carried out on a PP surface by oxygen plasma activation. The variation of grafting parameters, such as monomer concentration, reaction temperature and reaction time, as a function of the degree of grafting was investigated. The graft distribution and surface homogeneity of the PP surfaces were evaluated using confocal microscopy, field emission scanning electron microscopy and atomic force microscopy. These surface characterizations led to information about the impact of grafts on the material surface. © 2023 Society of Industrial Chemistry.

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Surface Immobilization of Oxidized Carboxymethyl Cellulose on Polyurethane for Sustained Drug Delivery

Somani,

Verma,

Nonglang

et al. 2024

Macromolecular Bioscience

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Polyurethane (PU) has a diverse array of customized physical, chemical, mechanical, and structural characteristics, rendering it a superb option for biomedical applications. The current study involves modifying the polyurethane surface by the process of aminolysis (aminolyzed polyurethane; PU‐A), followed by covalently immobilizing Carboxymethyl cellulose (CMC) polymer utilizing Schiff base chemistry. Oxidation of CMC periodically leads to the creation of dialdehyde groups along the CMC chain. When the aldehyde groups on the OCMC contact the amine group on a modified PU surface, they form an imine bond. Scanning electron microscopy (SEM), contact angle, and X‐ray photoelectron spectroscopy (XPS) techniques are employed to analyze and confirm the immobilization of OCMC on aminolyzed PU film (PU‐O). The OCMC gel incorporates Nitrofurantoin (NF) and immobilizes it on the PU surface (PU‐ON), creating an antibacterial PU surface. The confirmation of medication incorporation is achieved using EDX analysis. The varying doses of NF have demonstrated concentration‐dependent bacteriostatic and bactericidal effects on both Gram‐positive and Gram‐negative bacteria, in addition to sustained release. The proposed polyurethane (PU‐ON) surface exhibited excellent infection resistance in in vivo testing. The material exhibited biocompatibility and is well‐suited for biomedical applications.

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Preparation of functional and reactive nanosilver nanogels using oxidized carboxymethyl cellulose

Cited by 10 publications

References 42 publications

Amination of Polyurethane for Designing Infection-Resistant Surfaces

Amination of Polyurethane for Designing Infection-Resistant Surfaces

Functional surfaces by plasma grafting of itaconic acid onto polypropylene mesh: synthesis and structural investigations

Surface Immobilization of Oxidized Carboxymethyl Cellulose on Polyurethane for Sustained Drug Delivery

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