2001
DOI: 10.1016/s0141-8130(01)00135-0
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Preparation of gellan sulfate as an artificial ligand for removal of extra domain A containing fibronectin

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Cited by 20 publications
(6 citation statements)
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“…The use of gellan gum in cartilage tissue engineering was pioneered by Oliveira et al and this gum has been successfully modified into an injectable cell‐laden hydrogel by oxidative cleavage as reported previously . Gellan sulfate (GS) was originally prepared by our group . Because GS has a heparin‐like activity, it has the capacity to bind heparin‐binding proteins such as TNC.…”
Section: Discussionmentioning
confidence: 99%
“…The use of gellan gum in cartilage tissue engineering was pioneered by Oliveira et al and this gum has been successfully modified into an injectable cell‐laden hydrogel by oxidative cleavage as reported previously . Gellan sulfate (GS) was originally prepared by our group . Because GS has a heparin‐like activity, it has the capacity to bind heparin‐binding proteins such as TNC.…”
Section: Discussionmentioning
confidence: 99%
“…Gellan sulfate has been prepared for use in various medical applications, for example, as an artificial ligand to remove the extra domain A containing fibronectin (EDA(+)FN) from the plasma of rheumatoid arthritis patients42, and as a novel anticoagulant43.…”
Section: Discussionmentioning
confidence: 99%
“…However, unlike heparin, gellan sulfate is a potential artificial ligand for EDA(+)FN from the plasma of rheumatoid arthritis patients because it does not bind to proteins such as plasma fibronectin and antithrombin III42. Yet, gellan sulfates with 17.5% sulfation or greater were found to be potent anticoagulants, like heparin in APTT assays by Miyamoto et al 43.…”
Section: Discussionmentioning
confidence: 99%
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“…In medicine field, the use of gellan has been investigated for tissue engineering (e.g., for cartilage reconstruction and guided bone regeneration) and wound healing (e.g., in wound dressings to inhibit postsurgical adhesion and scar formation). Gellan sulfate derivatives are promising materials for rheumatoid arthritis treatment, as they have a tendency for selective binding of fibronectin molecules ( Miyamoto et al, 2001 ), and for the development of cell-hybrid materials for artificial veins design due to the anticoagulant activity of such derivatives ( Miyamoto et al, 2002 ).…”
Section: Industrial and Biomedical Applicationsmentioning
confidence: 99%