2014
DOI: 10.1248/bpb.b14-00317
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Preparation of Goreisan Suppository and Pharmacokinetics of <i>trans</i>-Cinnamic Acid after Administration to Rabbits

Abstract: Goreisan suppository is prepared as a hospital preparation, and successfully used for the treatment of diarrhea and vomiting in young children with common cold. While clinical efficacy of the suppository has been reported, few studies have been carried out to clarify the preparation procedure and pharmacokinetics of the suppository. In this study, trans-cinnamic acid (CA) was used as a representative substance of goreisan constituents, and assayed by HPLC-UV. We investigated the properties of goreisan supposit… Show more

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