Preparation of graphene oxide-graphene quantum dots hybrid and its application in cancer theranostics

Kumawat, Mukesh Kumar; Thakur, Mukeshchand; Bahadur, Rohan; Kaku, Tanvi Sushil; Prabhuraj, R S; Ninawe, Akanksha; Srivastava, Rohit

doi:10.1016/j.msec.2019.109774

Cited by 82 publications

(41 citation statements)

References 53 publications

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“…56 The zeta potential of the GO and GQD nanoparticles was determined to −38 mV and −8 mV respectively, indicating differences in their surface-exposed functional groups. The measured zeta potential values agree well with those reported by others, 57 further supporting the synthesis of typical GO and GQD nanoparticles.…”

Section: Characterization Of Graphene Oxide (Go) and Graphene Quantumsupporting

confidence: 90%

Graphene oxide sheets and quantum dots inhibit α-synuclein amyloid formation by different mechanisms

et al. 2020

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Section: Characterization Of Graphene Oxide (Go) and Graphene Quantumsupporting

confidence: 90%

Graphene oxide sheets and quantum dots inhibit α-synuclein amyloid formation by different mechanisms

et al. 2020

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“…This is also a good evidence that PEGylation occurred regioselectively at both GO surfaces.The functionalization of GO sheets with PEG-Fol chains was also established by means of AFM and SEM microscopies (Figure 5).Figure 5ashows a typical dimensional distribution analysis of GO-PEG-Fol, where the presence of GO islands with a thickness of about 3.5 nm and a diameter of about 40 ± 4 nm can be observed. The increase of the nano-flakes thickness of about 2.5 nm can be explained with a homogeneous functionalization of the GO surface with Fol-PEG-CC chains of 2.5 kDa, corroborating UV and FTIR data [5,42]. It might be noticed that the small size and the narrow size distribution observed are suitable for biomedical applications, especially as carrier for anticancer drugs, since nanocarriers with dimensions between 20-50 nm allow enhanced in vivo bioavailability and tumor accumulation, thereby improving the effectiveness of anticancer treatments.…”

supporting

confidence: 74%

Folic acid-functionalized graphene oxide nanosheets via plasma etching as a platform to combine NIR anticancer phototherapy and targeted drug delivery

Mauro

Scialabba

Agnello

et al. 2020

Materials Science and Engineering: C

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PEGylated graphene oxide (GO) has shown potential as NIR converting agent to produce local heat useful in breast cancer therapy, since its suitable photothermal conversion, high stability in physiological fluids, biocompatibility and huge specific surface. GO is an appealing nanomaterial for potential clinical applications combining drug delivery and photothermal therapy in a single nanodevice capable of specifically targeting breast cancer cells. However, native GO sheets have large dimensions (0.5-5 m) such that tumor accumulation after a systemic administration is usually precluded. Herein, we report a step-by-step synthesis of folic acid-functionalized PEGylated GO, henceforth named GO-PEG-Fol, with small size and narrow size distribution (~30±5 nm), and the ability of efficiently converting NIR light into heat. GO-PEG-Fol consists of a nano-GO sheet, obtained by fragmentation of GO by means of non-equilibrium plasma etching, fully functionalized with folic acid-terminated PEG 2000 chains through amidic coupling and azide-alkyne click cycloaddition, which we showed as active targeting agents to selectively recognize breast cancer cells such as MCF7 and MDA-MB-231. The GO-PEG-Fol incorporated a high amount of doxorubicin hydrochloride (Doxo) (> 33%) and behaves as NIR-light-activated heater capable of triggering sudden Doxo delivery inside cancer cells and localized hyperthermia, thus provoking efficient breast cancer death. The cytotoxic effect was found to be selective for breast cancer cells, being the IC 50 up to 12 times lower than that observed for healthy fibroblasts. This work established plasma etching as a cost-effective strategy to get functionalized nano-GO with a smart combination of properties such as small size, good photothermal efficiency and targeted cytotoxic effect, which make it a promising candidate as photothermal agent for the treatment of breast cancer.

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“…The synergetic effects of PTT and PDT in this research resulted in treatment of cancer cells by both hyperthermia and oxidative stress. 169 Having an ideal photothermal sensitizer is a crucial tool in ablating destructive cells. Recently scientists have not been able to keep an eye away from graphene in this regard.…”

Section: Dovepressmentioning

confidence: 99%

“…The synergetic effects of PTT and PDT in this research resulted in treatment of cancer cells by both hyperthermia and oxidative stress. 169 …”

Section: Optical Imaging and Theranosticsmentioning

confidence: 99%

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

Hoseini‐Ghahfarokhi¹,

Mirkiani²,

Mozaffari³

et al. 2020

IJN

164

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Graphene, a wonder material, has made far-reaching developments in many different fields such as materials science, electronics, condensed physics, quantum physics, energy systems, etc. Since its discovery in 2004, extensive studies have been done for understanding its physical and chemical properties. Owing to its unique characteristics, it has rapidly became a potential candidate for nano-bio researchers to explore its usage in biomedical applications. In the last decade, remarkable efforts have been devoted to investigating the biomedical utilization of graphene and graphene-based materials, especially in smart drug and gene delivery as well as cancer therapy. Inspired by a great number of successful graphene-based materials integrations into the biomedical area, here we summarize the most recent developments made about graphene applications in biomedicine. In this paper, we review the up-to-date advances of graphene-based materials in drug delivery applications, specifically targeted drug/ gene delivery, delivery of antitumor drugs, controlled and stimuli-responsive drug release, photodynamic therapy applications and optical imaging and theranostics, as well as investigating the future trends and succeeding challenges in this topic to provide an outlook for future researches.

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Preparation of graphene oxide-graphene quantum dots hybrid and its application in cancer theranostics

Cited by 82 publications

References 53 publications

Graphene oxide sheets and quantum dots inhibit α-synuclein amyloid formation by different mechanisms

Graphene oxide sheets and quantum dots inhibit α-synuclein amyloid formation by different mechanisms

Folic acid-functionalized graphene oxide nanosheets via plasma etching as a platform to combine NIR anticancer phototherapy and targeted drug delivery

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

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