Preparation of Growth Hormone from Pituitaries of Man and Monkey

Raben, M. S.

doi:10.1126/science.125.3253.883

Cited by 184 publications

(54 citation statements)

References 5 publications

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“…HGK (prepared according to the method of RABEN [21]) WaS injected by the rapid i.v. route and the modifications of glucose and FFA were followed for 4 h. 3.…”

Section: Human Growth Hormone (Hgh) Studies 10 Mg Ofmentioning

confidence: 99%

Influence of norepinephrine, growth hormone and fasting on FFA mobilization and glucose metabolism in lean and obese subjects

Balasse

1968

Diabetologia

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Summary. The influence of norepinephrine (NE), human growth hormone (I-IGH) and fasting on FFA mobilization and carbohydrate metabolism has been studied in 47 obese females and 72 nonobese control subjects (35 females and 37 males). --Weight-related doses of l~E infused for 2 h (0.1 y/kg/min) induced a much greater rise in plasma FFA and blood glucose concentrations in obese than in normal subjects. With a fixed dose (10 y/rain for 2 h), FFA response was still significantly higher in the overweight than in the lean subjects, while glucose reponses were similar in both groups. Among the control subjects, males and females behaved simflarily. --The plasma FFA rise observed in the 4 h following the g.v. injection of HGI-I (10 rag) was not statistically different in obese females, normal males and normal females. --These results suggest that human obese adipose tissue has no impaired sensitivity toward the lipolytic action of NE and HGH. --During fasting, obese, when compared with normal subjects, showed a smaller increase in plasma FFA level together with a smaller decrease in glucose flux. The possible relationship between these 2 anomalies is discussed, considering that glucose deficiency has a major role in regulating FFA mobilization during fasting. Influence de la noradrdnalinc, de ~'hormone de troissauce et du ~e~ne sur la mobitisation des F~FA et sur le m~tabolisme glucidique chez des 8ujets ob~ses et normaux

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“…HGK (prepared according to the method of RABEN [21]) WaS injected by the rapid i.v. route and the modifications of glucose and FFA were followed for 4 h. 3.…”

Section: Human Growth Hormone (Hgh) Studies 10 Mg Ofmentioning

confidence: 99%

Influence of norepinephrine, growth hormone and fasting on FFA mobilization and glucose metabolism in lean and obese subjects

Balasse

1968

Diabetologia

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“…HGH prepared according to the method of Raben (28) was administered successfully to 6 of these 14 patients. Cases AN, EG, and RR received 5 mg twice a week for 2 years.…”

Section: Stjbjectsmentioning

confidence: 99%

Subcutaneous Adipose Tissue and Lipids in Blood in Growth Hormone Deficiency before and after Treatment with Human Growth Hormone

Bonnet

Vanderschueren-Lodeweyckx

Eeckels

et al. 1974

Pediatr Res

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ExtractGH is necessary for the replication of subcutaneous adipose ceFls. It has also been shown that successful treatment of This study was undertaken to evaluate adipose cell size amd hygopjtuitary patients with WGH reduces skinfold number and subcutaneous fat and blosd lipids composition in the first months-Thereaftm, skinfold thickness hypopituitary ~a t i e n t s before and during treatment with. inGzeaa progressiveky and mturns to pretreatment values human growth hormone (BGH). The investigations were which E e att*ed aftm 4-5 y a r s of t h e~a p y (1, 26, 27, 32, performed in 14 prepubertal children 6-11 11/12 y e a s of 33). age, with idiopathic hypopituitarism. Human growth h o m a n e B~~~~~~ madjficatiolts d adipocfles explain the was administered successfully to 6 of these 14 patients for at changes in skhfold tkcknem observed dun;ng treatment with least 1 year.HGH, this study was, under;t&en to emluate adipose cell size Before HGH treatment there was a significant reduction of and nmber and subcutme~pus fat and blood composiadipose tissue cell number according to chronologic age and t o ti,n ini h y g o p i t~t w y p8ieIrEts before and dm.g skeletal age. The average adipose cell size was significantky HGH. larger than normal. A significant correlation between subcutaneous adipose cell mean-weight and tricipital and subscapular skinfold thickness, similar to that observed in normal children, was observed. The distribution of fatty acids in the subcutaneous fat and in the blood lipid composition was normal.During the 1st and 2nd year of HGH treatment, the total number of adipose cells increased rapidly. There was also a highly significant reduction of the average adipose cell size after the 1st year. A significant reduction of the fatty acids unsaturated fraction was observed after the 1st year without further changes after the 2nd year of treatment. The blood lipid composition did not change significantly after either 1 or 2 years of HGH treatment. SpeculationThe striking increase in total number of adipose cells observed during HGH administration in hypopituitary patients tends to prove that the adipose tissue organogenesis is not limited to a finite period ending after the 1st year of life.The modifications in composition of adipose tissue triglycerides induced by long term treatment with HGH would mean that the several components of the fatty acid pool are differentially liberated.The importance of growth hormone (GH) for the multiplication of muscle, cartilage, or liver cells has been well established both in man and in animals (9). Brook (7) has shown that at the end of intrauterine growth and during the first year of life, MATERIALS AND METHOID& STJBJECTSThe investigations were performed int 14 prepubertal children, 10 boys and 4 girls, 6-1 7 11/12 years of age, with idiopathic hypopituitarism. Clinical data are su~nmarized in Table I. G r o u p I contains the hypopituitary subjects who have been treated subsequently with HGH, whereas group I1 consists of patients untreated SKI far. The standa...

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“…14 " 16 These observations prompted renewed interest in the study of the role of growth hormone in human diabetes at a time when growth hormone prepared from human 17 and simian pituitaries 18 was found to be metabolically active in man.…”

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confidence: 99%

Growth Hormone and Diabetes Mellitus

Greenberg¹

1965

Diabetes

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Preparation of Growth Hormone from Pituitaries of Man and Monkey

Cited by 184 publications

References 5 publications

Influence of norepinephrine, growth hormone and fasting on FFA mobilization and glucose metabolism in lean and obese subjects

Influence of norepinephrine, growth hormone and fasting on FFA mobilization and glucose metabolism in lean and obese subjects

Subcutaneous Adipose Tissue and Lipids in Blood in Growth Hormone Deficiency before and after Treatment with Human Growth Hormone

Growth Hormone and Diabetes Mellitus

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