Preparation of Hetero‐π‐Conjugated Compounds by Double Nucleophilic Addition to Haloalkynes and C−H Cyclization
Takeshi Hata,
Yuta Tatsumi,
Yuki Kanai
et al.
Abstract:When a mixture containing 1‐halo‐1‐alkyne, a dinucleophilic agent, and a base (Cs<sub>2</sub>CO<sub>3</sub> or K<sub>3</sub>PO<sub>4</sub>) was heated in DMF, regio‐ and stereo‐selective nucleophilic addition of the dinucleophilic agent to the acetylenes occurred. This reaction yielded (<i>Z</i>,<i>Z</i>)‐bis(haloalkene), which subsequently underwent Pd‐catalyzed cyclization through C–H bond activation, resulting in the formation of two‐ox… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.