With
the accelerating trend of global aging, bone damage caused
by orthopedic diseases, such as osteoporosis and fractures, has become
a shared international event. Traffic accidents, high-altitude falls,
and other incidents are increasing daily, and the demand for bone
implant treatment is also growing. Although extensive research has
been conducted in the past decade to develop medical implants for
bone regeneration and healing of body tissues, due to their low biocompatibility,
weak bone integration ability, and high postoperative infection rates,
pure titanium alloys, such as Ti-6A1-4V and Ti-6A1-7Nb, although widely
used in clinical practice, have poor induction of phosphate deposition
and wear resistance, and Ti–Zr alloy exhibits a lack of mechanical
stability and processing complexity. In contrast, the Ti–Ni
alloy exhibits toxicity and low thermal conductivity. Nonthermal plasma
(NTP) has aroused widespread interest in synthesizing and modifying
implanted materials. More and more researchers are using plasma to
modify target catalysts such as changing the dispersion of active
sites, adjusting electronic properties, enhancing metal carrier interactions,
and changing their morphology. NTP provides an alternative option
for catalysts in the modification processes of oxidation, reduction,
etching, coating, and doping, especially for materials that cannot
tolerate thermodynamic or thermosensitive reactions. This review will
focus on applying NTP technology in bone implant material modification
and analyze the overall performance of three common types of bone
implant materials, including metals, ceramics, and polymers. The challenges
faced by NTP material modification are also discussed.