Preparation of Highly Transparent and Thermally Stable Films of <i>α</i>‐Cyclodextrin/Polymer Inclusion Complexes

Mori, Takafumi; Dong, Tungalag; Yazawa, Koji; Inoue, Yoshio

doi:10.1002/marc.200700502

Cited by 12 publications

(13 citation statements)

References 19 publications

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“…2B). 44 , 45 In PCL-α-CD IC, most crystalline diffraction peaks due to PCL disappeared, which indicated suppression of guest crystallization by formation of IC. New peaks at ~20° and ~22.5° appeared due to formation of IC 46 , 47 .…”

Section: Resultsmentioning

confidence: 99%

Multifunctional aliphatic polyester nanofibers for tissue engineering

et al. 2012

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Electrospun fibers based on aliphatic polyesters, such as poly(ε-caprolactone) (PCL), have been widely used in regenerative medicine and drug delivery applications due to their biocompatibility, low cost and ease of fabrication. However, these aliphatic polyester fibers are hydrophobic in nature, resulting in poor wettability, and they lack functional groups for decorating the scaffold with chemical and biological cues. Current strategies employed to overcome these challenges include coating and blending the fibers with bioactive components or chemically modifying the fibers with plasma treatment and reactants. In the present study, we report on designing multifunctional electrospun nanofibers based on the inclusion complex of PCL-α-cyclodextrin (PCL-α-CD), which provides both structural support and multiple functionalities for further conjugation of bioactive components. This strategy is independent of any chemical modification of the PCL main chain, and electrospinning of PCL-α-CD is as easy as electrospinning PCL. Here, we describe synthesis of the PCL-α-CD electrospun nanofibers, elucidate composition and structure, and demonstrate the utility of functional groups on the fibers by conjugating a fluorescent small molecule and a polymeric-nanobead to the nanofibers. Furthermore, we demonstrate the application of PCL-α-CD nanofibers for promoting osteogenic differentiation of human adipose-derived stem cells (hADSCs), which induced a higher level of expression of osteogenic markers and enhanced production of extracellular matrix (ECM) proteins or molecules compared with control PCL fibers.

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Section: Resultsmentioning

confidence: 99%

Multifunctional aliphatic polyester nanofibers for tissue engineering

et al. 2012

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“…For the particular case of macromolecules, the penetration of the chains into the empty cavity of the CDs and the corresponded rearrangement of the nanostructure can lead to well organized inclusion complexes (ICs) 3. ICs have been produced with biodegradable aliphatic polyesters, such as poly( ε ‐caprolactone),4–6 poly(lactic acid),6–8 or poly(butylene succinate) 5. Such polymers have been proposed for a variety of applications, especially in the environmental and biomedical fields.…”

Section: Introductionmentioning

confidence: 99%

Thermal Behaviour and Glass Transition Dynamics of Inclusion Complexes of α‐Cyclodextrin with Poly(D,L‐lactic acid)

Mano

2008

Macromol. Rapid Commun.

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Inclusion complexes (ICs) have been prepared by the host–guest interaction between α‐cyclodextrin (αCD) and poly(d,l‐lactic acid) (PDLLA). This enables transformation of the amorphous polymer into a well organized channel‐type crystalline structure, as studied by wide angle X‐ray scattering (WAXS). WAXS experiments using synchrotron radiation allowed the evolution of this crystalline structure to be followed upon heating. The diffraction peaks disappeared above 320 °C, in a temperature region similar to the occurrence of thermal degradation, also investigated by thermogravimetric analysis. No glass transition could be detected in the IC using differential scanning calorimetry (DSC), but non‐conventional dynamic mechanical analysis measurements revealed the existence of loss factor peaks shifted to higher temperatures when compared with PDLLA. The relaxation plot of the IC was characterized by an Arrhenius behaviour with a high activation energy that could be consistent with the high geometrical confinement felt by the chains in the nanostructured organization.

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“…Thus future approach is to improve thermal resistance of blended plastics [39]. In another study the bioplastic films by blending alpha cyclodextrin and poly capro lactone has been prepared with expected transparency and high heat resistance [40]. The blending between biodegradable polymers PHB with nondegradable polymer Low Density Poly Ethylene (LDPE) has been performed and remarkably the study claims to solve the problem of low water resistance and low elasticity of Bioplastic [41].…”

Section: Alternatives Of Plastic Polymersmentioning

confidence: 99%

Bioplastic Feasibility: Plastic Waste Disaster Management

Lakhawat¹,

Singh²,

Kumar³

et al. 2020

jcr

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The bioplastics and biodegradable plastics represent the special class of plastics which are produced by using biological processes and are biodegradable in nature. The manufacturing of bioplastic is different in comparison to biodegradable plastics. The biodegradable plastics are ecofriendly in nature and hence leave no waste. They are manufactured from the mixture of biopolymer and bioplasticizer.The biodegradable plastics suffers from certain weakness such as low water resistance, weak tensile strength etc. which can be improved using Electrospun technology. Comparatively the plastics are very toxic in nature when subjected to heat .The plasticizers such as Phthalate leaches from the plastic surface upon heating and it is a proven carcinogen. The recent studies on bioplastics focuses upon the food grade bioplastic packaging.The replacement of plastic with bioplastic in near future is strictly possible by controlling the cost of production.

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Preparation of Highly Transparent and Thermally Stable Films of α‐Cyclodextrin/Polymer Inclusion Complexes

Cited by 12 publications

References 19 publications

Multifunctional aliphatic polyester nanofibers for tissue engineering

Multifunctional aliphatic polyester nanofibers for tissue engineering

Thermal Behaviour and Glass Transition Dynamics of Inclusion Complexes of α‐Cyclodextrin with Poly(D,L‐lactic acid)

Bioplastic Feasibility: Plastic Waste Disaster Management

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