Preparation of indole-phosphine oxazoline (IndPHOX) ligands and their application in allylic alkylation

Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties

“…Compound 8 has the molecular formula C 7 H 10 N 2 O 2 (4 degrees of unsaturation), as deduced from its HRESIMS, 13 13 C NMR and DEPT spectra shows that this substance contains 7 carbons comprised of 2 CH 2 (one oxygenated), 4 CH (three aromatic, one oxygenated aliphatic), and 1C (aromatic). The 1 H-1 H COSY spectrum of 8 exhibits the correlations of H-1/H-2/H-3 and H-5 0 /H-6 0 .…”

“…The structure of compound 1, having the molecule formula C 11 H 14 N 4 O 3 , was assigned by using a combination of HRESIMS, 13 C NMR and DEPT spectroscopic methods. The 1 H-1 H COSY spectrum exhibits correlations of H-2 0 /H-3 0 /H-4 0 /H-5 0 /H-6 0 .…”

“…The molecular formula of compound 3 was determined to be C 12 H 19 N 5 O based on its HREIMS, 13 C NMR and DEPT spectroscopic data. The 1 H-1 H COSY spectrum exhibits correlations of H-2/H-3/H-4/H-5/H-6, which when considered along with the chemical shi of C-1 0 at d C 172.4, demonstrate the presence of a hexanoic acid residue.…”

“…The molecule formula of 4 was assigned as C 11 H 17 N 5 O by analysis of its HREIMS, 13 The lack of an optical rotation indicates that 4 is a racemate. Chiral HPLC separation afforded (+)-4 (4a) and (À)-4 (4b) whose ratio is 62 : 38.…”

“…Analysis of HREIMS, 13 , which in conjunction with the carbon chemical shis suggest that the arene ring C-3 and C-4 carbons are oxygenated. The 13 C NMR and DEPT spectra contain signals for 10 carbons attributed to 1 CH 3 , 5 CH (all aromatic), and 4C.…”