Preparation of indoles via iron catalyzed direct oxidative coupling

Abstract

Iron-catalyzed aryl C-H and vinyl C-H bonds activation to give valuable substituted indole products was reported. The reaction shows high functional group tolerance.

Exploring the Oxidative Cyclization of Substituted N‐Aryl Enamines: Pd‐Catalyzed Formation of Indoles from Anilines

“…In the aftermath of our communication, [11] this strategy was skillfully utilized by the groups of Jiao, Zhao, Cacchi, and Liang. [27] Their reported methods represent attractive indole formations with attractive features, such as using no toxic Pd catalyst or utilizing oxygen as the terminal oxidant. [27] All these studies provide new or improved synthetic routes to valuable indoles and new preparative applications for biologically active indole-based molecules.…”

“…[27] Their reported methods represent attractive indole formations with attractive features, such as using no toxic Pd catalyst or utilizing oxygen as the terminal oxidant. [27] All these studies provide new or improved synthetic routes to valuable indoles and new preparative applications for biologically active indole-based molecules. Furthermore, a one-pot reaction sequence enables rapid access to indoles from commercially available anilines.…”

Biocatalytic Enantioselective Oxidative CC Coupling by Aerobic CH Activation

“…In particular, the formation of C À C bonds by organo-or metal-catalyzed activation of C À H bonds [1] has recently obtained increased attention. [2] However, to the best of our knowledge, no biocatalytic oxidative CÀC bondforming reaction has yet been exploited for synthetic purposes. To date, biocatalysis only offers a limited number of enzymes for synthetic CÀC bond formation, [3] such as aldolases, [4] transketolases [4d, 5] and hydroxynitrile lyases, [3,6] and thiamine diphosphate (ThDP)-dependent enzymes.…”

Effiziente und vielseitige Indol‐Synthese aus Enaminen und Iminen mithilfe dehydrierender Kreuzkupplung

“…[8] Liang et al entwickelten eine eisenkatalysierte Synthese ausgehend von N-Arylenaminonen. [9] Dennoch limitieren die speziellen Startmaterialien die mçglichen Produkte (Schema 2).…”