Preparation of lipid nanoparticles by micro-mixer Process simulation and experimental study
Bing Li,
Hao Miao,
Zhenbo Tong
Abstract:Controlling the sizes of liposomes is critical in drug delivery systems because it directly influences their cellular uptake, transportation, and accumulation behaviour. Although micro-mixer has frequently been employed when synthesizing nano‑sized liposomes, little is known regarding how flow characteristics determine liposome formation. The mixing performance of a three-dimensional micromixer with a herringbone groove structure was studied by numerical analysis, and its structure was optimized. The model was… Show more
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