Preparation of Lutein-Loaded PVA/Sodium Alginate Nanofibers and Investigation of Its Release Behavior

Abstract

This investigation aims to study the characteristics and release properties of lutein-loaded polyvinyl alcohol/sodium alginate (PVA/SA) nanofibers prepared by electrospinning. In order to increase PVA/SA nanofibers’ water-resistant ability for potential biomedical applications, the electrospun PVA/SA nanofibers were cross-linked with a mixture of glutaraldehyde and saturated boric acid solution at room temperature. The nanofibers were characterized using scanning electron microscopy (SEM) and X-ray diffractometer (XRD). Disintegration time and contact angle measurements testified the hydrophilicity change of the nanofibers before and after cross-linking. The lutein release from the nanofibers after cross-linking was measured by an ultraviolet absorption spectrophotometer, which showed sustained release up to 48 h and followed anomalous (non-Fickian) release mechanism as indicated by diffusion exponent value obtained from the Korsmeyer–Peppas equation. The results indicated that the prepared lutein-loaded PVA/SA nanofibers have great potential as a controlled release system.

Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing

“…On comparing the R 2 values of the formulations, it was found that betulin release from the electrospun PVA could be best fitted by the Korsmeyer–Peppas model as this model showed higher R 2 values than all the other models. From the Korsmeyer–Peppas model, n values were found to be between 0.41 and 0.48 for all dressings, indicating that betulin release from PVA/TE fiber mats can be largely described as matrix diffusion [ 51 , 52 ]. This is in perfect agreement with the spatial distribution of the colloidal TE dispersion within PVA found by confocal Raman micro-spectroscopy, indicating that a hydrocolloid matrix is formed [ 32 ].…”

Docetaxel-Loaded Disulfide Cross-Linked Nanoparticles Derived from Thiolated Sodium Alginate for Colon Cancer Drug Delivery

“…The release data of fDMP2 were well fitted to the Higuchi model (high correlation coefficient values, R 2 , ≥0.83) for all of the parameters evaluated, showing that DTX is released by diffusion and dissolution mechanisms resulting from the degradation of disulfide cross-linked polymer ( Table 5). In Korsmeyer-Peppas's model, the drug release is regarded as Fickian diffusion if n (release exponent) is less than 0.45; non-Fickian diffusion if 0.45 < n < 0.89; super case-II transport (zero-order) if n > 0.89 [75]. Therefore, n is 0.64 in simulated colon condition for fDMP2, confirming that drug release follows non-Fickian diffusion and is coupled with erosion mechanisms.…”

Encapsulation of a Neutral Molecule into a Cationic Clay Material: Structural Insight and Cytotoxicity of Resveratrol/Layered Double Hydroxide/BSA Nanocomposites

“…Several reports showed that the release of a drug over a long period of time led to a more efficient delivery and less side effects [39,40]: the biphasic and prolonged release profile resulting from a single dose of the LDH-BSA could benefit therapeutic treatment, as the initial fast release quickly allows establishment of a therapeutic dose, and the subsequent sustained release allows maintenance of this dose over a long period of time. As shown in the Figure 6, the drug encapsulation inside LDH and LDH-BSA modified its release profile.…”