Preparation of magnetic metal‐organic framework MIL‐101(Fe) and its application in the extraction of anthraquinones in rhubarb

Abstract

MIL-101(Fe)) was synthesized for the magnetic solid-phase extraction of three anthraquinones, including aloe-emodin, emodin, and physcion, in rhubarb. The Fe 3 O 4 @NH 2 -MIL-101(Fe) exhibits a high specific surface area of 259.2 m 2 /g with an average pore size of 6.0 nm and high magnetic responsivity of 23.4 emu/g, which may be used as an adsorbent for rapid preconcentration and separation of target analytes. The main parameters for magnetic solid-phase extraction of anthraquinones, including the amount of adsorbent, extraction time, extraction temperature, extraction pH, elution solvent, and elution time, were systematically optimized. The whole extraction process requires a very low amount of adsorbent and a small volume of the sample. Besides, under the optimized conditions, the method shows satisfactory spiked recovery for anthraquinones in the range of 93.3-109.1% and the limits of detection are 1.7-3.4 ng/mL. The relative standard deviations for intra-and inter-day precision are 0.2-1.3% and 0.2-0.6%, respectively. The experimental results indicate that the developed method is feasible for the analysis of anthraquinones in rhubarb.

Magnetic solid‐phase extraction of warfarin and gemfibrozil in biological samples using polydopamine‐coated magnetic nanoparticles via core‐shell nanostructure

“…The overall results confirmed that our proposed method is simple, easy, relatively fast, repeatable, and sensitive [16,[18][19][20][21][22][23][24][25][26].…”

“…Warfarin causes anticoagulant effects by reducing the synthesis of coagulation factors dependent on vitamin K, and the use of this drug in high concentrations causes fatal bleeding [19]. The high tendency of warfarin to interact with other drugs, the limit and small range of its therapeutic concentration, and the variability of the optimal dose in different patients are the other problems in prescribing this drug [20]. Gemfibrozil is used to decrease the low-density lipoprotein cholesterol and triglycerides and increase the level of high-density lipoprotein in the blood.…”

Solid‐phase adsorption methodologies of naturally occurring anthraquinones: A review

“…The most recent acquisition in the field of coated magnetic nanoparticles was that reported by X. Zhou and coworkers. 23 These authors described (1) the synthesis of a magnetic octahedral Fe(III)organic framework having 2-aminoterephthalic acid as the ligand of the metal center named Fe 3 O 4 @NH2-MIL-101(Fe) and ( 2) its application to the adsorption of aloe-emodin (6), emodin (1), and physcion (3) in rhubarb extracts. After structural characterization, this novel sorbent exhibited a large specific surface area of 259.2 m 2 /g with an average pore size of 6.0 nm and a high magnetic responsivity of From the literature survey reported above, it is evident how coated magnetic nanoparticles have found wide use for SPE of anthraquinones from different vegetable sources.…”

“…The most recent acquisition in the field of coated magnetic nanoparticles was that reported by X. Zhou and coworkers 23 . These authors described (1) the synthesis of a magnetic octahedral Fe(III)‐organic framework having 2‐aminoterephthalic acid as the ligand of the metal center named Fe 3 O 4 @NH2‐MIL‐101(Fe) and (2) its application to the adsorption of aloe‐emodin ( 6 ), emodin ( 1 ), and physcion ( 3 ) in rhubarb extracts.…”

Magnetic porous carbon derived from NH2‐MIL‐101(Fe) as an adsorbent for the magnetic solid‐phase extraction of anthraquinones

“…It is a good adsorption material in MOFs and a potential carbonization precursor. In our previous study, a magnetic octahedral MOF Fe 3 O 4 @NH 2 ‐MIL‐101(Fe) was synthesized for the MSPE of three AQs, including aloe‐emodin, emodin, and physcion in rhubarb [27]. In this study, the typical Fe‐based MOF (MIL‐101) was used as a precursor and directly carbonized in a nitrogen atmosphere to prepare a magnetic nanoporous carbon (NH 2 ‐MIL‐101‐C).…”