Preparation of mangosteen extract-loaded poly(vinyl acetate) for use as an antibacterial spray-on dressing

Boonmak, Nattapol; Niyompanich, Jitti; Chuysinuan, Piyachat; Niamlang, Pimolpun; Ekabutr, Pongpol; Supaphol, Pitt

doi:10.1016/j.jddst.2018.05.033

Cited by 23 publications

(16 citation statements)

References 28 publications

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“…Different types of dressing materials are commercially available, such as: Algisite M, Tegaderm™ hydrocolloid dressing, Evicel ® , Coseal ® , and Elasto-Gel™ [ 3 , 6 ]. Nowadays, there is a high availability of wound treatment options that contain additional natural components, such as: manuka honey [ 7 , 8 , 9 ], Aloe vera [ 10 , 11 , 12 , 13 ], Echinacea purpurea [ 14 ], Calendula officinalis [ 11 ], Centella asiatica [ 15 ], Azadirachta indica [ 16 , 17 ], Tecomella undulate [ 18 , 19 ], Hypericum perforatum [ 20 , 21 ], Garcinia mangostana [ 22 , 23 ], Tectona grandis [ 24 ] as well as glycerin [ 25 , 26 , 27 ]. The active substances (saponins, tannins, flavonoids, alkaloids and quinones) that are present in the herbal extracts or hydrolats can ensure further therapeutic effects, such as antimicrobial, antioxidant, antibacterial and anti-inflammatory [ 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application

Bialik-Wąs

Pluta

Barczewski

et al. 2021

IJMS

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The impact of different amounts of glycerin, which was used in the system of sodium alginate/poly(vinyl alcohol) (SA/PVA) hydrogel materials on the properties, such as gel fraction, swelling ability, degradation in simulated body fluids, morphological analysis, and elongation tests were presented. The study shows a significant decrease in the gel fraction from 80.5 ± 2.1% to 45.0 ± 1.2% with the increase of glycerin content. The T5 values of the tested hydrogels were varied and range from 88.7 °C to 161.5 °C. The presence of glycerin in the matrices significantly decreased the thermal resistance, which was especially visible by T10 changes (273.9 to 163.5 °C). The degradation tests indicate that most of the tested materials do not degrade throughout the incubation period and maintain a constant ion level after 7-day incubation. The swelling abilities in distilled water and phosphate buffer solution are approximately 200–300%. However, we noticed that these values decrease with the increase in glycerin content. All tested matrices are characterized by the maximum elongation rate at break in a range of 37.6–69.5%. The FT-IR analysis exhibits glycerin changes in hydrogel structures, which is associated with the cross-linking reaction. Additionally, cytotoxicity results indicate good adhesion properties and no toxicity towards normal human dermal fibroblasts.

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Section: Introductionmentioning

confidence: 99%

The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application

Bialik-Wąs

Pluta

Barczewski

et al. 2021

IJMS

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“…Natural products can overcome some of the key issues with the widespread use of synthetic antimicrobial agents by reducing side effects and the occurrence of drug resistant pathogens [60]. Natural components including aloe, cellulose, natural plant extracts, and fish skin collagen have been studied as chronic and burn wound dressings [90][91][92][93][94][95][96].…”

Section: Alternative Antimicrobial Treatmentsmentioning

confidence: 99%

“…Depending on the polymer composition, hydrogels can be formulated for biodegradation, possibly eliminating the need for removal [129,130]. As wound dressings, they cover the wound and protect the exposed area, maintain a moist wound environment, absorb wound exudate, and can provide antimicrobial properties [40,90,[131][132][133][134]. Because of the variety of microorganisms found in infected wounds, hydrogels that can deliver antibiotics or are inherently antimicrobial may provide critical wound treatment [15,22].…”

Section: Hydrogelsmentioning

confidence: 99%

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

et al. 2020

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The epidermal skin barrier protects the body from a host of daily challenges, providing protection against mechanical insults and the absorption of chemicals and xenobiotics. In addition to the physical barrier, the epidermis also presents an innate defense against microbial overgrowth. This is achieved through the presence of a diverse collection of microorganisms on the skin (the “microbiota”) that maintain a delicate balance with the host and play a significant role in overall human health. When the skin is wounded, the local tissue with a compromised barrier can become colonized and ultimately infected if bacterial growth overcomes the host response. Wound infections present an immense burden in healthcare costs and decreased quality of life for patients, and treatment becomes increasingly important because of the negative impact that infection has on slowing the rate of wound healing. In this review, we discuss specific challenges of treating wound infections and the advances in drug delivery platforms and formulations that are under development to improve topical delivery of antimicrobial treatments.

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“…Results showed that the cumulative release of extract was found to be 30.30% to 48.80% after 60 hours in an acetate buffer solution and 41.13% to 49.96% in a phosphate buffer solution. The film containing mangosteen is found to improve antimicrobial activity and also noncytotoxic . In another study, Panawes et al developed an antimicrobial wound dressing incorporating the fruit hull of Garcinia mangostana (MT) extracts into sodium alginate (AG)‐coated gauze.…”

Section: Herbal Constituents‐incorporated Wound Dressingmentioning

confidence: 99%

Recent advances on herb‐derived constituents‐incorporated wound‐dressing materials: A review

Thomas

2019

Polymers for Advanced Techs

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Since ancient times, wound dressings have evolved with persistent and substantial changes. Several efforts have been made toward the development of new dressing materials, which can meet the demanding conditions for the treatment of skin wounds. Currently, many studies have been focused on the production and designing of herb‐incorporated wound dressings. Herb‐derived constituents are more effective than conventional medicines because of their nontoxic nature and can be administered over long periods. Herbal medicines in wound healing provide a suitable environment for aiding the natural course of healing. This review mainly focuses on the diverse approaches that have been developed to produce a wound dressing material, which can deliver herb‐derived bioactive constituents in a controlled manner. This review also discusses the common wound‐dressing materials available, basic principles of wound healing, and wound‐healing agents from medicinal plants.

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Preparation of mangosteen extract-loaded poly(vinyl acetate) for use as an antibacterial spray-on dressing

Cited by 23 publications

References 28 publications

The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application

The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

Recent advances on herb‐derived constituents‐incorporated wound‐dressing materials: A review

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