Preparation of Mefenamic Acid Sprays as Analgesic for Wide Range of Oral Diseases and Their Clinical Evaluation

Arai, Nanayo; Watanabe, Machiko; Kurashige, Megumi; Yanagi, Mashiho; Nishizawa, Satoru; Ando, Takahito; Chigono, Yoshiho; Hirabayashi, Shinichi; Matsuda, Juzo; Yamaoka, Kunihiro; Inoue, Keizō

doi:10.5649/jjphcs.32.648

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“…External formulations that relieve oral pain includê lms, sprays, 7) ointments, and mouthwashes. Film formulations can particularly improve patient QOL because of better localization and drug retention times, as well as protective coverage of the aŠected site.…”

Section: Introductionmentioning

confidence: 99%

Controlled Indomethacin Release from Mucoadhesive Film: <i>In Vitro</i> and Clinical Evaluations

et al. 2008

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To develop aˆlm formulation allowing controlled release for long-term analgesia, we selected ethyl cellulose (EC) as a novel additive, prepared aˆlm formulation using indomethacin (IMˆlm), and evaluated it in vitro and clinically. In the in vitro experiments, the eŠects of the EC concentration on the release rate of IM and on the adhesion force to the mucous membrane were investigated. The addition of 10％ EC resulted in more sustained slow release compared with no EC, and the adhesion of theˆlm with 10％ EC added was similar to that ofˆlms containing carboxyvinyl polymer, which we reported previously showed signiˆcantly increased adhesion. A two-layeredˆlm consisting of an adhesive layer with 2％ or 1％ IM and 10％ EC and a nonadhesive layer with 2％ polyethylene glycol as a softening agent, was investigated for clinical use. Film consisting of an adhesive layer with 2％ IM and 10％ EC exhibited rapid onset of potent analgesia and was expected to prolong the duration of analgesia. These results suggest that IMˆlm with EC added may be useful clinically, since it shows both immediate analgesic eŠects and prolonged duration of release.

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Section: Introductionmentioning

confidence: 99%