Preparation of microcapsules from complex coacervation of Gantrez-gelatin. II.In vitrodissolution of nitrofurantoin microcapsules

Abstract

Nitrofurantoin crystals were encapsulated in a Gantrez-gelatin complex coacervation system. The encapsulation process was reproducible and inexpensive and the microcapsules were free flowing and directly compressible into tablets. In vitro release of nitrofurantoin from Gantrez-gelatin microcapsules was studied as a function of the core:coat ratio, the molecular weight of Gantrez and the particle size of the microcapsules. The release of the drug was significantly reduced using G149-gelatin microcapsules of core:coat ratio of 1:2. Release data were examined kinetically and were found to follow a diffusion-controlled model. In vitro release of the drug from the microcapsules filled in capsules and compressed into tablets confirmed the efficiency of the encapsulation process for preparing prolonged release formulations.

Sustained-release dosage form of nitrofurantoin. Part 1. Preparation of microcapsules and in vitro release kinetics

“…Ethyl cellulose, gelatin, gelatin-pepton and glyceryl monostearate (Chowdary et al 1985 a-c), ethyl cellulose (Hashim et al 1987), gantrez-gelatin (Mortada et al 1987), and polycaprolactone (Dubernet et al 1987) were used for microencapsulation of nitrofurantoin recently. In this work carboxymethylcellulose was used as repeatedly.…”