Preparation of microcapsules with self-microemulsifying core by a vibrating nozzle method

Abstract

Incorporation of drugs in self-microemulsifying systems (SMES) offers several advantages for their delivery, the main one being faster drug dissolution and absorption. Formulation of SMES in solid dosage forms can be difficult and, to date, most SMES are applied in liquid dosage form or soft gelatin capsules. This study has explored the incorporation of SMES in microcapsules, which could then be used for formulation of solid dosage forms. An Inotech IE-50 R encapsulator equipped with a concentric nozzle was used to produce alginate microcapsules with a self-microemulsifying core. Retention of the core phase was improved by optimization of encapsulator parameters and modification of the shell forming phase and hardening solution. The mean encapsulation efficiency of final batches was more than 87%, which resulted in 0.07% drug loading. It was demonstrated that production of microcapsules with a self-microemulsifying core is possible and that the process is stable and reproducible.

Microencapsulation of self-microemulsifying system: Improving solubility and permeability of furosemide

“…When CaCl 2 was added to SMES in higher amounts the microencapsulation process was disabled by clogging of the nozzle. A similar effect was observed previously (Homar et al, 2007).…”

“…The qualitative composition of SMES was selected on the basis of our previous work (Špiclin et al, 2003;Homar et al, 2007). SMES with different oil phase/surfactant ratios were tested to obtain the composition having the highest furosemide loading capacity (Fig.…”

“…SMES are usually filled in soft gelatin capsules, but they can also be transformed into granules, pellets, powders for dry filled capsules or tablet preparations (Nazzal and Khan, 2006;Serratoni et al, 2007;Abdalla et al, 2008;Tan et al, 2009). In our previous study an innovative approach of incorporating SMES into Ca-alginate microcapsules by using vibrating nozzle method has been reported (Homar et al, 2007). However, this initially developed method has not been sufficiently optimized in order to enable repeatable production of microcapsules with high encapsulation efficiency.…”

Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies

“…In terms of EE%, high values were achieved for all NPs prepared due to the poor solubility of CB13 in the external aqueous phase, 24 and highest values were achieved using Resomer 502. Panyam et al 25 demonstrated that when hydrophobic drugs are used, NPs drug loading is closely matched with the respective solid-state drug-polymer solubility, that is, the ability of the polymeric matrix to entrap drug in the dispersed state.…”

Solid self-nanoemulsifying cyclosporin A pellets prepared by fluid-bed coating: preparation, characterization and in vitro redispersibility

“…[11][12][13][14][15] Spray-drying has also been employed to formulate liquid SNEDDSs into free-flowing powders, using adsorbents such as Aerosil 200 16 and dextran. 17 Homar et al 18 and Zvonar et al 6 reported microencapsulation of liquid SNEDDSs to obtain solid powders of microcapsules. The powders containing liquid SNEDDS can be further formulated into solid dosage forms, such as tablets, capsules, and granules.…”