Preparation of Micron-Sized Di-Functional Magnetic Composite Polymer Particles

Abstract

In this investigation micron-sized monodisperse magnetic composite polymer particles with amino and amide functional groups were prepared considering their applications in biotechnology. First, polystyrene/poly (acrylic acid-acrylam- ide-N-N-methylene-bis-acrylamide) [PS/P(AA-AAm-MBAAm)] composite polymer particles were prepared by seeded copolymerization. The carboxyl groups present on or near the particles surface were modified by amine-nucleophile, ethylene diamine (EDA), through pre-activation with dicyclohexyl carbodiimide as coupling agent. The aminated particles were then magnetically modified and named as aminated-Fe3O4 composite particles. Formation of such magnetic composite particles was confirmed by scanning electron micrographs, FTIR-spectra and magnetic susceptibility measurement. The produced composite particles were paramagnetic. To see the relative hydrophilic character of the particles surface the adsorption behavior of trypsin (TR) as biomolecule was studied on PS particles and aminated-Fe3O4 composite particles. The magnitude of adsorbed TR on PS particles was higher than that on aminated-Fe3O4 composite particles

Preparation of hydrophobic polymer particles by radical polymerization and subsequent modification into magnetically doped particles

“…A comparative plot of FTIR spectra of Fe 3 O 4 particles and washed P(LMA‐MMA)/Fe 3 O 4 composite particles stabilized by PVA and PVP is shown in Figure 10. In the FTIR spectrum of Fe 3 O 4 , the characteristic broad stretching vibrations due to FeO bonds of Fe 3 O 4 particles appeared at 582.5 cm −1 and 357 cm −1 , respectively, as also reported elsewhere 24–26. Both spectra of magnetically doped composite particles exhibited similar but weak signal at 580 cm −1 and 353 cm −1 , respectively.…”

Fractional statistical theory of adsorption applied to protein adsorption

“…The protein adsorption onto polymer particles has been studied for decades because of its significant interest in a wide range of applications in biology, medicine, and biotechnology [1][2][3][4][5][6][7][8][9][10][11][12]. The particles used for that purpose are generally copolymerized, or their surfaces are modified chemically and/or biologically [10][11][12][13][14].…”

Processing and characterization of injection moldable polymer–particle composites applicable in brazing processes

“…Composites based on thermoplastic matrices and functionalized micro‐ and nanoparticles are used for numerous applications regarding the functional properties and the content of filler particles, as well as the properties of polymer matrices 1–5. The main advantage of polymer–particle composites is the easy and cost‐efficient process ability in kneading, extrusion and injection molding processes at filler contents up to 70 vol % 6.…”