Preparation of molecularly imprinted polymers in supercritical carbon dioxide

Ye, Lei; Yoshimatsu, Keiichi; Kolodziej, Dorota; Francisco, José da Cruz; Dey, Estera Szwajcer

doi:10.1002/app.24648

Cited by 42 publications

(23 citation statements)

References 43 publications

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“…[1][2][3] It has been shown that molecularly imprinted polymers (MIPs) possess high selectivity and sensitivity for template molecules including drugs, 4 environmental contaminants, 5 nucleotide bases, 6 protein, 7 even chemical warfare agents. 8 These MIPs demonstrate very good thermal and mechanical stability and can be used in aggressive media.…”

Section: Introductionmentioning

confidence: 99%

Preparation and selective binding characterization of Bisphenol A imprinted polyethersulfone particles

Yang

Zhou

et al. 2007

J of Applied Polymer Sci

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Bisphenol A (BPA) imprinted polyethersulfone (PES) particles were prepared for the recognition of BPA by means of phase inversion method. During the preparation of the BPA-imprinted particles, acetone, ethanol and acetone/ethanol solutions were used to extract the template BPA molecules. The SEM morphology and the recognition experiments suggested that the acetone/ethanol provided an efficient way to extract the BPA from the imprinted PES particles. The binding and recognition ability for the imprinted particles disappeared under alkali condition, and they recovered as soon as possible when the solution changed from alkali condition to neutral or acid condition. With the addition of Na 1 , Mg 21 , and Cl 2 , the binding amounts for the imprinted particles and nonimprinted particles were not changed heavily, which suggested the potential application of the particles in seawater. In the BPA/BPA analogue mixed solution, the imprinted particles showed selectivity for the template molecules BPA. The FTIR results suggested that the PES and BPA interacted through hydrogen bonds.

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Section: Introductionmentioning

confidence: 99%

Preparation and selective binding characterization of Bisphenol A imprinted polyethersulfone particles

Yang

Zhou

et al. 2007

J of Applied Polymer Sci

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“…Thus the combination of MAA and DVB was deemed to be the most suitable for the development of subsequent MIPs. This combination of a cross linker and a functional monomer has been used previously in the development of selective MIPs [31][32][33][34][35]. MIPs were subsequently synthesised using[BMIM][BF 4 ] (MIP BF4 ), [BMIM][PF 6 ] (MIP PF6 ) and CHCl 3 (MIP CHCl3 ) as the porogens.…”

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confidence: 99%

Ionic liquids as porogens for molecularly imprinted polymers: propranolol, a model study

et al. 2014

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The selectivity and rebinding capacity of molecularly imprinted polymers selective for propranolol (1) using the room temperature ionic liquids [BMIM][BF4], [BMIM][PF6], [HMIM][PF6] and [OMIM][PF6] and CHCl3 were examined. The observed IF (imprinting factor) values for MIPBF4, MIPPF6 and MIPCHCl3 were 1.0, 1.98 and 4.64, respectively. The longer chain HMIM and OMIM systems returned lower IF values of 1.1 and 2.3, respectively. MIPPF6 also showed a 25% binding capacity reduction vs. MIPCHCl3 (5 μmol g(−1)vs. 7 μmol g(−1) respectively). MIPCHCl3 and MIPPF6 differed in terms of BET surface area (306 m(2) g(−1)vs. 185 m(2) g(−1)), pore size (1.10 and 2.19 nm vs. 0.97 and 7.06 nm), the relative number of pores (Type A: 10.4 vs. 7.5%; Type B: 8.5 vs. 3.0%), and surface zeta potential (−37.9 mV vs. −20.3 mV). The MIP specificity for 1 was examined by selective rebinding studies with caffeine (2) and ephedrine (3). MIPPF6 rebound higher quantities of 2 than MIPCHCl3, but this was largely due to non-specific binding. Both MIPCHCl3 and MIPPF6 showed a higher affinity for 3 than for 2. Reduction in the Room Temperature Ionic Liquid (RTIL) porogen volume had little impact on the polymer morphology, but did result in a modest decrease in IF from 2.6 to 2.3 and in the binding capacity (30% to 19%). MIPCHCl3 retained the highest template specificity on rebinding from CHCl3 (IF = 4.6) dropping to IF = 0.6 in MeOH/[BMIM][PF6]. The MIPCHCl3 binding capacity remained constant using CHCl3, CH2Cl2 and MeOH (46–52%), dropped to 6% on addition of [BMIM][PF6] and increased to 83% in H2O (but at the expense of specificity with IFH2O = 1.4). MIPPF6 rebinding from MeOH saw an increase in specific rebinding to IF = 4.9 and also an increase in binding capacity to 48% when rebinding 1 from MeOH and to 42% and 45% with H2O and CH2Cl2, respectively, although in the latter case the increased capacity was at the cost of specificity with IFCH2Cl2 = 1.2. Overall the MIPPF6 capacity and specificity were enhanced on addition of MeOH.

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“…Supercritical CO2-assisted molecular imprinting has recently demonstrated to be a clean and one-step synthetic route for the preparation of MIPs, with attested performance in chromatography [ 47 ], drug delivery [67,68,69], and extraction [70,71,72,73]. The advantages of using scCO2 as solvent in the molecular imprinting process go beyond environmental concerns.…”

Section: Supercritical Co2-assisted Synthesis Of Mipsmentioning

confidence: 99%