Preparation of molecularly imprinted polymers using theanine as dummy template and its application as SPE sorbent for the determination of eighteen amino acids in tobacco

Zhu, Fengling; Wang, Jing; Zhu, Lijun; Lanlan, Tan; Guanglin, Feng; Liu, Shaomin; Dai, Ya Ji; Wang, Hua

doi:10.1016/j.talanta.2015.12.038

Cited by 40 publications

(18 citation statements)

References 54 publications

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“…Copyright 2012, Elsevier); C) schematic procedure of dummy template molecular imprinting on the surface of vinyl‐SiO 2 microspheres. Reproduced with permission . Copyright 2016, Elsevier; D) a new IL‐based MIP was prepared by ion‐pair dummy template imprinting, which confined the charged monomer in the imprinting cavities.…”

Section: Biological Molecular Imprinting With Different Scalementioning

confidence: 99%

“…This method is advantageous for the simultaneous determination of homolog compounds. For example, as shown in Figure C, a dummy template anine‐imprinted polymer (DMIPs) using vinyl‐SiO 2 microspheres as substrate was prepared via surface imprinting technique by Zhu et al A high performance liquid chromatography for the simultaneous determination of eighteen amino acids in tobacco was prepared using the resulting DMIPs as sorbents for solid phase extraction . In addition, the suitable “dummy” template could contribute to the improvement of specific selectivity for the target template .…”

Section: Biological Molecular Imprinting With Different Scalementioning

confidence: 99%

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Molecularly Imprinted Materials for Selective Biological Recognition

Zhang

et al. 2019

Macromol. Rapid Commun.

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Molecular imprinting is an approach of generating imprinting cavities in polymer structures that are compatible with the target molecules. The cavities have memory for shape and chemical recognition, similar to the recognition mechanism of antigen–antibody in organisms. Their structures are also called biomimetic receptors or synthetic receptors. Owing to the excellent selectivity and unique structural predictability of molecularly imprinted materials (MIMs), practical MIMs have become a rapidly evolving research area providing key factors for understanding separation, recognition, and regenerative properties toward biological small molecules to biomacromolecules, even cell and microorganism. In this review, the characteristics, morphologies, and applicability of currently popular carrier materials for molecular imprinting, especially the fundamental role of hydrogels, porous materials, hierarchical nanoparticles, and 2D materials in the separation and recognition of biological templates are discussed. Moreover, through a series of case studies, emphasis is given on introducing imprinting strategies for biological templates with different molecular scales. In particular, the differences and connections between small molecular imprinting (bulk imprinting, “dummy” template imprinting, etc.), large molecular imprinting (surface imprinting, interfacial imprinting, etc.), and cell imprinting strategies are demonstrated in detail. Finally, future research directions are provided.

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Section: Biological Molecular Imprinting With Different Scalementioning

confidence: 99%

Section: Biological Molecular Imprinting With Different Scalementioning

confidence: 99%

Molecularly Imprinted Materials for Selective Biological Recognition

Zhang

et al. 2019

Macromol. Rapid Commun.

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“…Phenylalanine and tyrosine are generally recommended as antidepressants for mood elevating or appetite control, and tryptophan is used for promoting the release of neurotransmitter serotonin, which is favor of sleep regulation. The concentration of free amino acids in body fluids can be used to diagnose inborn errors of metabolism . The detection of amino acid in biomedical and pharmaceutical studies is growing, and several analytical devices and methods such as HPLC , GC , CE–MS and LC–MS have been reported for this purpose.…”

Section: Introductionmentioning

confidence: 99%

“…The concentration of free amino acids in body fluids can be used to diagnose inborn errors of metabolism [1][2][3][4]. The detection of amino acid in biomedical and pharmaceutical studies is growing, and several analytical devices and methods such as HPLC [5], GC [6], CE-MS [7] and LC-MS [8] have been reported for this purpose.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound‐assisted low‐density‐solvent‐based solvent‐demulsified dispersive liquid–liquid microextraction for the quantification of amino acids in biological samples

Zare

Razmi

2018

Separation Science Plus

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An ultrasound‐assisted low‐density‐solvent‐based solvent‐demulsified dispersive liquid–liquid microextraction followed by high‐performance liquid chromatography with ultraviolet detection method has been established for the purpose of microextraction and recognition of tyrosine, phenylalanine and tryptophan from plasma and urine samples. For the preconcentration of analytes, 10 mL of sample solution was placed in test tube. A blend of 200 μL 1‐dodecanol and 100 μL acetonitrile were quickly injected into the sample solution and then shaken for 4.8 min using ultrasonic irradiation. The addition of demulsifier into the formed emulsion results in rapid separation of the mixture into two phases. The central composite design was used for optimization of microextraction conditions. Under the optimized conditions, the calibration graphs of tyrosine, phenylalanine and tryptophan were linear in the range of 1–200 μmol L−1. Limits of detection and quantification were 0.17–0.32 and 0.64–1.09 μmol L−1, respectively. This procedure was successfully used to determine target analytes in spiked plasma and urine samples; the relative mean recoveries ranged from 84.7 to 96.4%.

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“…Moreover, the multi-step swelling and polymerization method showed considerable separation ability (Haginaka, Sanbe, & Takehira, 1999;Hosoya et al, 1995). The structural analogs of the target molecules, namely the dummy template, can avoid the leakage of the template of the analyte (He, Chen, Wang, & Tan, 2017;Hu et al, 2014;Liang et al, 2016;Zhu et al, 2016). In order to obtain sufficient selectivity and capacity, the selection of the dummy template is a key factor, while the available dummy template molecules are limited, especially for the simultaneous determination of homologous compounds.…”

Section: Introductionmentioning

confidence: 99%

Preparation of dummy template‐imprinted polymers for the rapid extraction of nonsteroidal anti‐inflammatory drugs residues in aquatic environmental samples

Zhang

Chen

Zhao

2018

Biomedical Chromatography

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A molecularly imprinted polymer was synthesized and applied as a sorbent in the solid-phase extraction device. The imprinted polymer was characterized by fourier-transform infrared spectroscopy and scanning electron microscope. The results revealed that imprinted polymer possess sensitive selectivity and reliable adsorption properties for five NSAIDs. The imprinted polymer was successfully applied to the pre-concentration for five NSAIDs in different water samples prior to UPLC-MS/MS. In the early studies, several factors were investigated, including pH adjustment, the kind of elution solvent and the volume of elution solvent. Finally, we found that the pH 5 and an aliquot of 2 mL methanol were suitable for the water samples. The limits of detection and limits of quantitation of five nonsteroidal anti-inflammatory drugs varied from 0.007 to 0.480 μg L and 0.03 to 1.58 μg L , respectively. The spiking recoveries of the target analytes were 50.33-127.64% at the levels of 0.2 μg L , 2 μg L and 5 μg L . The precision and accuracy of this method showed a great increase compared with traditional solid-phase extraction. The developed method was successfully applied to extraction and analysis of NSAIDs in different water samples with satisfactory results which could help us better understand their environmental fate and risk to ecological health.

show abstract

Preparation of molecularly imprinted polymers using theanine as dummy template and its application as SPE sorbent for the determination of eighteen amino acids in tobacco

Cited by 40 publications

References 54 publications

Molecularly Imprinted Materials for Selective Biological Recognition

Molecularly Imprinted Materials for Selective Biological Recognition

Ultrasound‐assisted low‐density‐solvent‐based solvent‐demulsified dispersive liquid–liquid microextraction for the quantification of amino acids in biological samples

Preparation of dummy template‐imprinted polymers for the rapid extraction of nonsteroidal anti‐inflammatory drugs residues in aquatic environmental samples

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