Preparation of monoclonal antibodies for detection of recombinant flagellin C from <i>Pseudomonas Aeruginosa</i>
Anton P. Zherebtsov,
I. V. Yakovleva,
N. F. Gavrilova
et al.
Abstract:An important virulence factor in the pathogenesis of infections caused by Pseudomonas aeruginosa is flagellin: it serves as the main structural component of the bacterial flagellum and an acceptor for the TLR5 receptor of the innate immune system. Toll-like receptor 5 is able to bind bacterial flagellin and activate the anti-inflammatory transcription factor NF-kB through the adapter protein MyD88, which induces the production of anti-inflammatory cytokines. The inclusion of flagellin in recombinant proteins i… Show more
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