Preparation of monodisperse silica-polyacrylamide hybrid particles with snowman or core-shell morphologies using a microfluidic device

Nemoto, Hikaru; Shimba, Daigo; Kanai, Toshimitsu

doi:10.1080/21870764.2022.2055858

Cited by 5 publications

(4 citation statements)

References 45 publications

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“…Tailorable infusion composition is attainable with a narrow particle size distribution. Previous work has demonstrated tunability of particle size as a function of precursor constituent molar ratios, microfluidic flow rates, and channel dimensions of the device chip. − We aim to carry out similar investigations for silica particles fabricated with radioactive precursors in a future study. Alterations of the sol recipe and microfluidic device features enable personalized, point-of-care treatments by fitting specific patient attributes or requirements.…”

Section: Discussionmentioning

confidence: 98%

Microfluidic Fabrication of Silica Microspheres Infused with Positron Emission Tomography Imaging Agents

Larsen

López

Selwyn

et al. 2023

ACS Appl. Bio Mater.

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Selective internal radiation therapy (SIRT) is a treatment which delivers radioactive therapeutic microspheres via the hepatic artery to destroy tumorigenic tissue of the liver. However, the dose required varies significantly from patient to patient due to nuances in individual biology. Therefore, a positron emission tomography (PET) imaging surrogate, or radiotracer, is used to predict in vivo behavior of therapeutic Y-90 spheres. The ideal surrogate should closely resemble Y-90 microspheres in morphology for highest predictive accuracy. This work presents the fabrication of positron-emitting silica microspheres infused with PET radiotracers copper, fluorine, and gallium. A quick one-pot synthesis is used to create precursor sol, followed by droplet formation with flow-focusing microfluidics, and finally thermal treatment to yield 10–50 μm microspheres with narrow size distribution. Loading of the infused element is controllable in the sol synthesis, while the final sphere size is tunable based on microfluidic flow rates and device channel width. The system is then employed to make radioactive Ga-68 microspheres, which are tested for radioactivity and stability. The fabrication method can be completed within a few hours, depending on the desired microsphere quantity. A microfluidic system is applied to fabricate silica particles loaded with diverse elemental infusions, including radioactive Ga-68.

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Section: Discussionmentioning

confidence: 98%

Microfluidic Fabrication of Silica Microspheres Infused with Positron Emission Tomography Imaging Agents

Larsen

López

Selwyn

et al. 2023

ACS Appl. Bio Mater.

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“…The multitude of their application in drug loading and delivery, chemical sensors, tissue engineering, and water-holding agents , has attracted widespread interest in the scientific community. Smart hydrogels are, in particular, one of the most promising materials . Due to the existence of specific functionalities or adjustable cross-links, smart hydrogels in their swollen state can undergo significant changes by absorbing or expelling water in response to changes in their external environment, including ionic strength or pH, , temperature, , substrate concentration, − electric signal and light, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Smart hydrogels are, in particular, one of the most promising materials. 6 Due to the existence of specific functionalities or adjustable cross-links, smart hydrogels in their swollen state can undergo significant changes by absorbing or expelling water in response to changes in their external environment, including ionic strength or pH, 7,8 temperature, 9,10 substrate concentration, 11−13 electric signal and light, etc. Lately, stimuli-responsive hydrogel materials have piqued a great deal of interest in account of their preponderant properties in the field of medicine, 14−16 sensors 17 and chemical separation, 18,19 etc.…”

Section: ■ Introductionmentioning

confidence: 99%

Multichannel Multijunction Droplet Microfluidic Device to Synthesize Hydrogel Microcapsules with Different Core–Shell Structures and Adjustable Core Positions

Wu,

Huang,

Liu

et al. 2023

Langmuir

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Core−shell hydrogel microcapsules have sparked great interest due to their unique characteristics and prospective applications in the medical, pharmaceutical, and cosmetic fields. However, complex synthetic procedures and expensive costs have limited their practical application. Herein, we designed and prepared several multichannel and multijunctional droplet microfluidic devices based on soft lithography for the effective synthesis of core−shell hydrogel microcapsules for different purposes. Additionally, two different cross-linking processes (ultraviolet (UV) exposure and interfacial polymerization) were used to synthesize different types of core−shell structured hydrogel microcapsules. Hydrogel microcapsules with gelatin methacryloyl (GelMA) as the core and polyacrylamide (PAM) as the thin shell were synthesized using UV cross-linking. Using an interfacial polymerization process, another core−shell structured microcapsule with GelMA as the core and Ca 2+ cross-linked alginate with polyethylenimine (PEI) as the shell was constructed, and the core diameter and total droplet diameter were flexibly controlled by carving. Noteworthy, these hydrogel microcapsules exhibit stimuli-responsiveness and controlled release ability. Overall, a novel technique was developed to successfully synthesize various hydrogel microcapsules with core−shell microstructures. The hydrogel microcapsules possess a multilayered structure that facilitates the coassembly of cells and drugs, as well as the layered assembly of multiple drugs, to develop synergistic therapeutic regimens. These adaptable and controllable hydrogel microdroplets shall held great promise for multicell or multidrug administration as well as for high-throughput drug screening.

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“…The synthesis of monodispersed silica-polyacrylamide (PAAM) hydrogel hybrid particles with coreshell or snowman morphologies using a microfluidic device was recently reported. 24) Monodispersed droplets of sodium silicate solution prepared by the device react with an aqueous solution containing sodium hydrogen carbonate (NaHCO 3 ) and acrylamide (AAM), and it was found that the coreshell or snowman morphologies could be easily controlled by varying the concentration of the AAM monomer. However, when preparing silica-PNIPAM hybrid particles, the morphologies cannot be controlled by varying the N-isopropylacrylamide (NIPAM) monomer concentration in the range where sufficient polymer networks were formed.…”

Section: Introductionmentioning

confidence: 99%

Microfluidics-based preparation of thermosensitive monodispersed silica-PNIPAM hybrid particles with core–shell or snowman morphologies

Kanai,

Shimba,

Oketani

et al. 2023

J. Ceram. Soc. Japan

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Organicinorganic hybrid particles have unique properties derived from the combination of their constituents and morphology, thereby enabling them to perform crucial functions in applications across the biomedicine, pharmaceutical, cosmetic, materials science, and engineering industries. This paper reports a method for preparing monodispersed hybrid particles comprising silica and thermosensitive poly(N-isopropylacrylamide) (PNIPAM) hydrogel particles with coreshell or snowman morphologies using a microfluidic device. Here, monodispersed droplets of sodium silicate solution are generated using a flow-focusing microfluidic device. When sodium hydrogen carbonate (NaHCO 3 ) and N-isopropylacrylamide (NIPAM) are simultaneously transferred to the droplets, sodium silicate reacts with NaHCO 3 to form coreshell structures, wherein silica-rich droplets are generated inside the NIPAM-rich droplets. The droplets are subsequently irradiated with ultraviolet (UV) light to yield monodispersed silica-PNIPAM hydrogel coreshell particles. However, when only NaHCO 3 is transferred to the sodium-silicate solution droplets, a snowman-like structure comprising silica-rich and waterrich droplets is formed. Therefore, NIPAM can be transferred to water-rich droplets and photopolymerized via UV light irradiation to obtain monodispersed snowman-like silica-PNIPAM hydrogel hybrid particles. Furthermore, the PNIPAM hydrogel hybrid-particle size can be easily altered by changing the temperature to approximately the human body temperature.

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Preparation of monodisperse silica-polyacrylamide hybrid particles with snowman or core-shell morphologies using a microfluidic device

Cited by 5 publications

References 45 publications

Microfluidic Fabrication of Silica Microspheres Infused with Positron Emission Tomography Imaging Agents

Microfluidic Fabrication of Silica Microspheres Infused with Positron Emission Tomography Imaging Agents

Multichannel Multijunction Droplet Microfluidic Device to Synthesize Hydrogel Microcapsules with Different Core–Shell Structures and Adjustable Core Positions

Microfluidics-based preparation of thermosensitive monodispersed silica-PNIPAM hybrid particles with core–shell or snowman morphologies

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