Preparation of Monodisperse Solid Fat Microspheres in a Microfluidic Device

Nakatsuka, A.; Matsuo, Aya; Kanai, Toshimitsu

doi:10.1252/jcej.15we279

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…e micro uidic technique (Whitesides, 2006;Kanai et al, 2011;Ohtani et al, 2014;Kanai and Tsuchiya, 2016;Nakatsuka et al, 2016) is one of the most powerful tools for generating highly monodispersed microbubbles with a strictly controlled size; however, the productivity of this method is lower than that of conventional methods such as sonication and mechanical agitation. When the gas and liquid phases are injected into each micrometer-sized ow channel so that the liquid phase shears the gas phase regu-larly, highly monodispersed microbubbles with a low coefcient of variation (CV) can be continuously generated.…”

Section: Introductionmentioning

confidence: 99%

Generation of Monodisperse Microbubbles with a Controlled Size of Less Than 10 µm at a Generation Rate on the Order of 10<sup>5</sup> Bubbles/s in Glass Capillary Microfluidic Devices

Kitazaki

Nemoto

Kanai

2021

J. Chem. Eng. Japan

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Inexpensive glass capillary micro uidic devices with co-ow geometry were prepared to generate highly monodispersed microbubbles with a controlled size of less than 10 µm for medical applications. In the analysis, the dimensions of the injection and collection capillaries were decreased, and the gas pressure and liquid phase ow rate were increased to their respective limits. The diameter of the monodisperse microbubbles (having a coe cient of variation of less than 1.5%) could be controlled within the range of 2.4-9.2 µm, while maintaining a generation rate on the order of 10 5 bubbles/s by adjusting the inner tip diameter of the injection capillary and the liquid phase ow rate. The inner diameter of the collection capillary was 30 µm, and the gas pressure was 0.50 MPa.

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Section: Introductionmentioning

confidence: 99%

Generation of Monodisperse Microbubbles with a Controlled Size of Less Than 10 µm at a Generation Rate on the Order of 10<sup>5</sup> Bubbles/s in Glass Capillary Microfluidic Devices

Kitazaki

Nemoto

Kanai

2021

J. Chem. Eng. Japan

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“…Many review articles have been published on the microfluidic processes used to produce droplets (Tumarkin and Kumacheva, 2009;Vladisavljević et al, 2012;Wang et al, 2014;Choi et al, 2017;Huang et al, 2017;Shang et al, 2017;Wang et al, 2017). The formed droplets have been utilized to produce microparticles; when the droplets formed in microfluidic devices are solidified, one can obtain micrometer-scale particles with highly controlled sizes and morphologies (Choi et al, 2008;Nakatsuka et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Multiphase Microfluidic Processes to Produce Alginate-Based Microparticles and Fibers

Yamada

Seki

2018

Journal of Chemical Engineering of Japan

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With the recent developments in micro uidic instruments and devices, various types of micrometer-sized materials have been produced by employing multiphase ow patterns formed in the microchannel. In particular, microparticles and micro bers, which are compatible with biomolecule incorporation or living cell encapsulations, have been gaining signi cant attention as new tools for biochemical analysis, cellular physiological studies, tissue engineering, cell transplantation, and controlled drug delivery. Herein, we introduce recent developments in micro uidic systems to produce alginate-based hydrogel microparticles and micro bers. By utilizing droplet dispersions either in equilibrium or nonequilibrium states, or by employing parallel laminar ows, microengineered functional materials that are di cult to generate using conventional devices and operations can be obtained. New and interesting multiphase phenomena are reviewed, together with the pros and cons of these systems and their applications. Furthermore, the fundamentals of multiphase micro uidics and the materials used to prepare particles and bers are brie y introduced.

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“…To treat substances showing high viscosity or crystalline (Cr) phase in the microcapillary systems, heating and solvent Please do not adjust margins Please do not adjust margins addition have been reported to be effective; microspheres consisting of oil with high melting points 22,23 and polymersomes 24 with a shell of solid polymers can be produced by using the microcapillary systems. As temperature increases, solid-to-liquid phase transitions occur and viscosities decrease.…”

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confidence: 99%

“…As temperature increases, solid-to-liquid phase transitions occur and viscosities decrease. 22,23 In fact, the fabrication of smectic A (SmA) and smectic C (SmC) LC microcapsules by using such heating systems have been reported. [25][26][27][28] However, since we cannot heat the system above the boiling point of water when we fabricate microcapsules with aqueous phases, it is impossible to use LC materials that cannot flow under 100°C.…”

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confidence: 99%

Room-temperature fabrication of mono-dispersed liquid crystalline shells with high viscosity and high melting points

et al. 2017

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Preparation of Monodisperse Solid Fat Microspheres in a Microfluidic Device

Cited by 8 publications

References 12 publications

Generation of Monodisperse Microbubbles with a Controlled Size of Less Than 10 µm at a Generation Rate on the Order of 10<sup>5</sup> Bubbles/s in Glass Capillary Microfluidic Devices

Generation of Monodisperse Microbubbles with a Controlled Size of Less Than 10 µm at a Generation Rate on the Order of 10<sup>5</sup> Bubbles/s in Glass Capillary Microfluidic Devices

Multiphase Microfluidic Processes to Produce Alginate-Based Microparticles and Fibers

Room-temperature fabrication of mono-dispersed liquid crystalline shells with high viscosity and high melting points

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