Preparation of monodisperse thermo-sensitive poly(N-isopropylacrylamide) hollow microcapsules

Cheng, Chang-Jing; Chu, Liang‐Yin; Ren, Ping-Wei; Zhang, Jie; Hu, Lin

doi:10.1016/j.jcis.2007.05.004

Cited by 67 publications

(46 citation statements)

References 32 publications

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“…In addition, Figure 3(C) showed that the coefficient of variance (CV) was below 1.8%, which proved that the resulting microspheres were highly monodisperse according to the US National Institute of Standards and Technology (NIST) definition of monodispersity as a narrow size distribution having a CV < 5%. 5,18,19 The polymerization of PEG microspheres was confirmed by analysis with Fourier transform infrared spectroscopy (FTIR) because it is a powerful tool used to identify specific chemical bonds simply by interpreting the infrared absorption spectrum. 3,20 Since the activated radicals initiates the polymerization by attacking the carbon-carbon double bonds (C=C) presents in two acrylate groups of PEG-DA prepolymer, the photopolymerization results not only in linear chain growth but also in crosslinked network, which produce insoluble polymer structures.…”

Section: Resultsmentioning

confidence: 99%

In situ microfluidic synthesis of monodisperse PEG microspheres

et al. 2009

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This study presents a microfluidic method for the production of monodisperse poly(ethylene glycol) (PEG) microspheres using continuous droplet formation and in situ photopolymerization in microfluidic devices. We investigated the flow patterns for the stable formation of droplets using capillary number and the flow rate of the hexadecane phase. Under the stable region, the resulting microspheres showed narrow size distribution having a coefficient of variation (CV) of below 1.8%. The size of microspheres (45~95 μm) could be easily controlled by changing the interfacial tension between the two immiscible phases and the flow rates of the dispersed or continuous phase.

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Section: Resultsmentioning

confidence: 99%

In situ microfluidic synthesis of monodisperse PEG microspheres

et al. 2009

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“…Monodisperse hollow poly(N-isopropylacrylamide) (PNIPAM) microcapsules were prepared combining membrane emulsifi cation and UV-initiated polymerization at the interface of W/O single emulsions at a temperature below the lower critical solution temperature of PNIPAM [37]. Before and aft er the polymerization, the span of the particles distribution was maintained at about 0.27.…”

Section: Temperature and Ph Responsive-materialsmentioning

confidence: 99%

Nanostructured Sensing Emulsion Droplets and Particles: Properties and Formulation by Membrane Emulsification

Piacentini¹,

Imbrogno²,

Giorno³

2014

Smart Membranes and Sensors

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Responsive particles can adapt to surrounding environments regulating the transport of molecules with specifi c functional activity or convert chemical and biochemical signals into optical, electrical, thermal and mechanical signals, and vice versa. Th ese materials are playing an increasingly important part in several ranges of applications, such as drug delivery, diagnostics, tissue engineering, biosensors, coatings and textiles. Microfabrication techniques which permit the creation of particles that possess a combination of structural and functional features have tremendous potential in the development of new products with improved quality for medical, food, cosmetic or chemical applications. Membrane emulsifi cation is relatively new technology for the precise, selective and fl exible manufacturing of micro-nano-particulates with target size, composition, structure and function. In this chapter, membrane emulsifi cation technology and its use in the preparation of sensing particles are presented.

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“…Formation of hollow microcapsules by direct injection of a gas into the capsule core is of particular interest [25][26][27][28][29][30][31][32][33][34]. Since the inner cavity and shell layer are formed directly in this technique, the number of materials available for capsule synthesis was significantly increased compared with single emulsion techniques using self-assembly or interfacial polymerization of the shell layer [35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Formation of Polymeric Hollow Microcapsules and Microlenses Using Gas-in-Organic-in-Water Droplets

et al. 2015

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This paper presents methods for the formation of hollow microcapsules and microlenses using multiphase microdroplets. Microdroplets, which consist of a gas core and an organic phase shell, were generated at a single junction on a silicon device without surface treatment of the fluidic channels. Droplet, core and shell dimensions were controlled by varying the flow rates of each phase. When the organic solvent was released from the organic phase shell, the environmental conditions changed the shape of the solidified polymer shell to either a hollow capsule or a microlens. A uniform solvent release process produced polymeric capsules with nanoliter gas core volumes and a membrane thickness of approximately 3 μm. Alternatively physical rearrangement of the core and shell allowed for the formation of polymeric microlenses. On-demand formation of the polymer lenses in wells and through-holes polydimethylsiloxane (PDMS) structures was achieved. Optical properties of the lenses were controlled by changing the dimension of these structures. OPEN ACCESSMicromachines 2015, 6 623

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Preparation of monodisperse thermo-sensitive poly(N-isopropylacrylamide) hollow microcapsules

Cited by 67 publications

References 32 publications

In situ microfluidic synthesis of monodisperse PEG microspheres

In situ microfluidic synthesis of monodisperse PEG microspheres

Nanostructured Sensing Emulsion Droplets and Particles: Properties and Formulation by Membrane Emulsification

Formation of Polymeric Hollow Microcapsules and Microlenses Using Gas-in-Organic-in-Water Droplets

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