Preparation of Multifunctional Fe@Au Core-Shell Nanoparticles with Surface Grafting as a Potential Treatment for  Magnetic Hyperthermia

Chung, Ren‐Jei; Shih, Hui-Ting

doi:10.3390/ma7020653

Cited by 30 publications

(26 citation statements)

References 19 publications

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“…The 2θ peaks at 38.67°, 44.81°, 64.4°, and 77.96° highlighted the (111), (200), (220), and (311) planes of face‐centered cubic (FCC) gold particles while the 2θ peaks at 43.9° and 64.8° highlighted the body‐centered cubic (BCC) planes of iron particles (Figure C). These results are consistent with those of our previous studies and other research groups, which indicates the presence of Fe and Au. To analyze the composition of each oFe@Au Np further, energy dispersive X‐ray spectroscopy (EDS) (Figure D) and inductively coupled plasma mass spectroscopy (ICP‐MS) were performed.…”

Section: Resultssupporting

confidence: 94%

“…To establish the potential of the oFe@Au‐MTX conjugate to be used as a drug‐releasing platform upon photo‐stimulation, oFe@Au‐MTX drug‐nanoparticle conjugates were exposed to laser light for different periods and the amount of MTX released was quantified using UV–vis spectroscopy. MTX usually shows a distant absorption peak at 304 nm, as observed in our previous studies . The presence of a distinct absorption peak at 304 nm in this study also indicated the presence of MTX.…”

Section: Resultssupporting

confidence: 90%

“…MTX usually shows a distant absorption peak at 304 nm, as observed in our previous studies. [34] The presence of a distinct absorption peak at 304 nm in this study also indicated the presence of MTX. UV-vis results also revealed that there was a time-dependent increase in the MTX concentration, which was signified by an increase in absorption at 304 nm that confirmed the applicability of oFe@Au nanoparticles as drug carriers (Figure 5 C).…”

Section: Photo-stimulated Heat Generation By Ofe@au Npssupporting

confidence: 64%

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Theranostic Iron@Gold Core–Shell Nanoparticles for Simultaneous Hyperthermia‐Chemotherapy upon Photo‐Stimulation

Dhawan

Wang

et al. 2019

Part & Part Syst Charact

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The challenges of nanoparticles, such as size‐dependent toxicity, nonbiocompatibility, or inability to undergo functionalization for drug conjugation, limit their biomedical application in more than one domain. Oval‐shaped iron@gold core–shell (oFe@Au) magnetic nanoparticles are engineered and their applications in magnetic resonance imaging (MRI), optical coherence tomography (OCT), and controlled drug release, are explored via photo stimulation‐generated hyperthermia. The oFe@Au nanoparticles have a size of 42.57 ± 5.99 nm and consist of 10.76 and 89.24 atomic % of Fe and Au, respectively. Upon photo‐stimulation for 10 and 15 minutes, the levels of cancer cell death induced by methotrexate‐conjugated oFe@Au nanoparticles are sixfold and fourfold higher, respectively, than oFe@Au nanoparticles alone. MRI and OCT confirm the application of these nanoparticles as a contrast agent. Finally, results of in vivo experiments reveal that the temperature is elevated by 13.2 °C, when oFe@Au nanoparticles are irradiated with a 167 mW cm−2 808 nm laser, which results in a significant reduction in tumor volume and scab formation after 7 days, followed by complete disappearance after 14 days. The ability of these nanoparticles to generate heat upon photo‐stimulation also opens new doors for studying hyperthermia‐mediated controlled drug release for cancer therapy. Applications include biomedical engineering, cancer therapy, and theranostics fields.

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Section: Resultssupporting

confidence: 94%

Section: Resultssupporting

confidence: 90%

Section: Photo-stimulated Heat Generation By Ofe@au Npssupporting

confidence: 64%

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Theranostic Iron@Gold Core–Shell Nanoparticles for Simultaneous Hyperthermia‐Chemotherapy upon Photo‐Stimulation

Dhawan

Wang

et al. 2019

Part & Part Syst Charact

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“…This can be achieved by combining two or more metal components into a single alloy or core-shell nanoparticle 2 3 . For biomedical applications, the gold-iron system is particularly interesting 4 5 6 7 . In this context, iron-based particles are relevant because of their magnetic properties that are applicable for magnetic resonance imaging (MRI) 8 and thermotherapy 9 , whereas gold is a promising material for its oxidation resistance, optical properties 10 , and ability to be easily functionalized by thiolated biomolecules 11 .…”

mentioning

confidence: 99%

Solvent-surface interactions control the phase structure in laser-generated iron-gold core-shell nanoparticles

Wagener

Jakobi

Rehbock

et al. 2016

Sci Rep

131

106

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This work highlights a strategy for the one-step synthesis of FeAu nanoparticles by the pulsed laser ablation of alloy targets in the presence of different solvents. This method allows particle generation without the use of additional chemicals; hence, solvent-metal interactions could be studied without cross effects from organic surface ligands. A detailed analysis of generated particles via transmission electron microscopy in combination with EDX elemental mapping could conclusively verify that the nature of the used solvent governs the internal phase structure of the formed nanoparticles. In the presence of acetone or methyl methacrylate, a gold shell covering a non-oxidized iron core was formed, whereas in aqueous media, an Au core with an Fe3O4 shell was generated. This core-shell morphology was the predominant species found in >90% of the examined nanoparticles. These findings indicate that fundamental chemical interactions between the nanoparticle surface and the solvent significantly contribute to phase segregation and elemental distribution in FeAu nanoparticles. A consecutive analysis of resulting Fe@Au core-shell nanoparticles revealed outstanding oxidation resistance and fair magnetic and optical properties. In particular, the combination of these features with high stability magnetism and plasmonics may create new opportunities for this hybrid material in imaging applications.

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“…MNPs show potential biomedical applications, such as localized cellular therapy, magnetically-guided drug delivery, magnetic resonance imaging (MRI), hyperthermia treatment, and magnetofection on the interaction with an external magnetic field [ 1 , 2 ]. Among MNPs, metallic iron nanoparticles (Fe NPs) have been studied and applied in the research fields of optics, catalysis, magnetism and biomedicine for years [ 3 , 4 , 5 ]. One benefit to prepare metallic iron NPs is that FeNPs have a much stronger shortening effect on T 2 relaxation time than iron oxide nanoparticles (IONPs), suggesting that FeNPs may be more effective MRI contrast agents [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of SiO2-Protecting Metallic Fe Nanoparticle/SiO2 Composite Spheres for Biomedical Application

2015

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Functionalized Fe nanoparticles (NPs) have played an important role in biomedical applications. In this study, metallic Fe NPs were deposited on SiO2 spheres to form a Fe/SiO2 composite. To protect the Fe from oxidation, a thin SiO2 layer was coated on the Fe/SiO2 spheres thereafter. The size and morphology of the SiO2@Fe/SiO2 composite spheres were examined by transmission electron microscopy (TEM). The iron form and its content and magnetic properties were examined by X-ray diffraction (XRD), inductively-coupled plasma mass spectrometry (ICP-MS) and a superconducting quantum interference device (SQUID). The biocompatibility of the SiO2@Fe/SiO2 composite spheres was examined by Cell Counting Kit-8 (CCK-8) and lactate dehydrogenase (LDH) tests. The intracellular distribution of the SiO2@Fe/SiO2 composite spheres was observed using TEM. XRD analysis revealed the formation of metallic iron on the surface of the SiO2 spheres. According to the ICP-MS and SQUID results, using 0.375 M FeCl3·6H2O for Fe NPs synthesis resulted in the highest iron content and magnetization of the SiO2@Fe/SiO2 spheres. Using a dye loading experiment, a slow release of a fluorescence dye from SiO2@Fe/SiO2 composite spheres was confirmed. The SiO2@Fe/SiO2 composite spheres co-cultured with L929 cells exhibit biocompatibility at concentrations <16.25 µg/mL. The TEM images show that the SiO2@Fe/SiO2 composite spheres were uptaken into the cytoplasm and retained in the endosome. The above results demonstrate that the SiO2@Fe/SiO2 composite spheres could be used as a multi-functional agent, such as a magnetic resonance imaging (MRI) contrast agent or drug carriers in biomedical applications.

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Preparation of Multifunctional Fe@Au Core-Shell Nanoparticles with Surface Grafting as a Potential Treatment for Magnetic Hyperthermia

Cited by 30 publications

References 19 publications

Theranostic Iron@Gold Core–Shell Nanoparticles for Simultaneous Hyperthermia‐Chemotherapy upon Photo‐Stimulation

Theranostic Iron@Gold Core–Shell Nanoparticles for Simultaneous Hyperthermia‐Chemotherapy upon Photo‐Stimulation

Solvent-surface interactions control the phase structure in laser-generated iron-gold core-shell nanoparticles

Preparation of SiO2-Protecting Metallic Fe Nanoparticle/SiO2 Composite Spheres for Biomedical Application

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