Preparation of Nanocomposite Hydrogels and Its in vitro Release Behaviour on Captopril

Abstract

Nanocomposite hydrogels are interesting for biomedical applications due to their bio compatibility and good water sorption diffusion properties. The pH sensitive interpenetrating polymer network based nanocomposite hydrogels was prepared from montmorillonite nanoclays by free radical polymerization and solvent sorption method was used for drug loading. Drug used was captopril an angiotensin converting enzyme inhibitor. Interactions and thermal stabilities were studied using fourier transform infrared spectroscopy, differential scanning calorimerty, thermogravimetric analysis. The morphology of the nanocomposite hydrogels was characterized by scanning electron microscopy (SEM), swelling study and per cent drug loading reveals the formation of compatible nanocomposite hydrogels. In vitro drug release in the pH of 1.2 and 7.4 fitted with kinetic equation models. This shows that the swelling ratios of the nanocomposite hydrogels has been influenced by the pH of the external media and also increased with an increasing order of clay addition, Drug loading of the gels increased with an increasing concentration of captopril. The fabricated formulation shows targeted release of the drug in intestine (pH 7.4).

Critical Review of Biodegradable and Bioactive Polymer Composites for Bone Tissue Engineering and Drug Delivery Applications

“…It was observed that the pH of the external media and the clay addition order had a profound effect on the swelling characteristics of nanocomposite hydrogels, as shown in Figure 26 . The targeted release of Captopril was observed in the intestine [ 322 ].…”

“… Influence of concentration on the cumulative percentage of drug delivery at ( a ) 0.05%, ( b ) 0.1%, and ( c ) 0.15% of capoten-loaded nanocomposite hydrogels. Reproduced with permission from [ 322 ]. …”

Additive Manufacturing of Bio and Synthetic Polymers

“…It was observed that the pH of the external media and the clay addition order had a profound effect on the swelling characteristics of nanocomposite hydrogels, as shown in Figure 26. The targeted release of Captopril was observed in the intestine [322]. Karak et al (2019), highlighted the fundamental concept of nanocomposites of polymers and nanomaterials.…”

“…S. Latha et al (2013) formulated hydrogels of Captopril nanocomposites. Due to their better diffusion, biocompatibility, and excellent water sorption, hydrogels have wide applicability in the biomedical field.…”

Karakteristik Fisik dan Laju Difusi In Vitro Sediaan Transdermal Patch Domperidon Menggunakan Polimer Turunan Metil Metakrilat-Asam Metakrilat

“…Saat ini, sediaan transdermal patch banyak digunakan sebagai sistem penghantaran obat dan kosmetik. Sediaan transdermal patch adalah sediaan farmasi non-invasif yang digunakan dengan cara ditempelkan di permukaan kulit yang memungkinkan penyerapan obat melalui kulit dengan keuntungan memberikan konsentrasi obat dalam plasma yang konstan, sehingga dapat meningkatkan bioavailabilitas dan meminimalkan potensi efek samping [4], Komposisi sediaan transdermal patch meliputi bahan aktif, matriks polimer, peningkat permeasi, dan pemlastis. Matriks polimer berfungsi sebagai kerangka dasar patch dan mengatur kecepatan pelepasan obat ke dalam kulit.…”