Preparation of nanoparticles by solvent displacement for drug delivery: A shift in the “ouzo region” upon drug loading

Beck-Broichsitter, Moritz; Rytting, Erik; Lebhardt, Tobias; Wang, Xiaoying; Kissel, Thomas

doi:10.1016/j.ejps.2010.06.007

Cited by 181 publications

(153 citation statements)

References 34 publications

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“…More particularly, the behavior observed in our study matches the work performed by Beck-Broichsitter et al 32 that showed that the incorporation of a small hydrophilic positively charged drug salbutamol had a significant shifting effect on the ouzo region of PLGA, that is, the region where polymer concentration and S-NS ratio allow formation of nanoparticle suspensions by the nanoprecipitation technique. More specifically, the authors proved that the incorporation of salbutamol in the organic phase allowed formation of a complex polymer-drug more soluble in water than the polymer alone, resulting in the formation of nanoparticles without aggregation for higher polymer concentrations as well as in a significant reduction of size characteristics for drug-loaded particles compared with the corresponding unloaded nanoparticles.…”

Section: Physicochemical Propertiessupporting

confidence: 92%

Development of biodegradable polymeric nanoparticles for encapsulation, delivery, and improved antifungal performance of natamycin

Bouaoud

Mendes

et al. 2016

J of Applied Polymer Sci

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The aim of this study was to evaluate biodegradable poly(lactide-co-glycolide) nanoparticles as potential nano-delivery systems for the food antifungal compound natamycin. Natamycin-loaded nanoparticles were prepared at various ratios polymer/antifungal by the nanoprecipitation technique, resulting in nano-size particles (80-120 nm) with a narrow distribution and a spherical morphology. Complexation of natamycin with PLGA and active participation to the nanoparticle formation were evidenced by a mean diameter reduction of 10-30 nm, although encapsulation levels remained low due to the zwitterionic and partially hydrophilic nature of natamycin. Physical state analyses highlighted the presence of natamycin in an amorphous or molecularly dispersed state within the polymeric matrix. This translates into high availability of free antifungal molecules reflected in burst release and fast in vitro release kinetics rates as well as enhanced antifungal performance against the model food yeast Saccharomyces cerevisiae, offering a potential benefit for antifungal protection compared with the commercially available natamycin products. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43736.

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Section: Physicochemical Propertiessupporting

confidence: 92%

Development of biodegradable polymeric nanoparticles for encapsulation, delivery, and improved antifungal performance of natamycin

Bouaoud

Mendes

et al. 2016

J of Applied Polymer Sci

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“…Nanoparticles were prepared by a modified solvent displacement method, as described elsewhere [17]. Briefly, solutions of PEGylated PLGA polymer (Resomer ® RGPd50105 and RGPd5055, Boehringer Ingelheim, Ingelheim am Rhein, Germany) were prepared at concentrations of 3 mg/ml in tetrahydrofuran (THF, Acros Organics, Geel, Belgium), along with digoxin (MP Biomedicals, LLC, CA, USA) at 5 and 10% theoretical drug loading, and allowed to mix overnight to ensure that both the drug and the polymer were completely dissolved in the solvent.…”

Section: Preparation Of Nanoparticlesmentioning

confidence: 99%

Transport of digoxin-loaded Polymeric Nanoparticles Across BeWo cells, an In Vitro Model of Human Placental Trophoblast

et al. 2015

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Background: Fetal arrhythmias can lead to fetal congestive heart failure and hydrops fetalis. Digoxin (the first-line treatment) has low transplacental permeability and high risk of maternal side effects. Biodegradable digoxin-loaded PEGylated poly(lactic-co-glycolic acid) nanoparticles may increase digoxin transport across BeWo b30 cell monolayers (an in vitro model of trophoblast in human placenta) by reducing the drug's interaction with P-gp. Results/methodology: The nanoparticles showed high encapsulation efficiency and sustained release over 48 h. Transport studies revealed significantly increased permeability across BeWo cell layers of digoxin-loaded nanoparticles when compared with free digoxin. P-gp inhibition also increased the permeability of digoxin, but not digoxin-loaded nanoparticles. Conclusion: This represents a novel treatment strategy for fetal cardiovascular disease which may improve maternal and fetal outcomes.

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“…The solvent is thereby totally miscible with the non-solvent. The nanoparticles are formed immediately by fast diffusion of the solvent into the non-solvent forming small nano-droplets, which are directly coated by stabilizer (9)(10)(11). This method is not limited to a specific polymer but can be transferred to many synthetic or natural polymers which are relevant as drug carrier materials (12).…”

Section: Introductionmentioning

confidence: 99%

Semi-Automated Nanoprecipitation-System—An Option for Operator Independent, Scalable and Size Adjustable Nanoparticle Synthesis

et al. 2014

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The preparation of nano-sized carrier systems increasingly moved into focus of pharmaceutical research and industry in the past decades. Besides the drug load and properties of the selected polymer/lipid, the size of such particles is one of the most important parameters regarding their use as efficient drug delivery systems.However, the preparation of nanoparticles with different sizes in a controlled manner is challenging, especially in terms of reproducibility and scale-up possibility. To overcome these hurdles we developed a system relying on nanoprecipitation, which meets all these requirements of an operator independent, scalable and size-adjustable nanoparticle synthesis -the Semi-Automated Nanoprecipitation-System. This system enables the adaption of the particle size to specific needs based on the process parameters -injection rate, flow rate and polymer concentration -identified within this study. The basic set-up is composed of a syringe pump and a gear pump for a precise control of the flow and injection speed of the system. Furthermore, a home-made tube-straightener guarantees a curvature-free injection point. Thus it could be shown that the production of poly(lactide-coglycolide) nanoparticles from 150-600 nm with a narrow size distribution in a controlled semi-automatic manner is possible.

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Preparation of nanoparticles by solvent displacement for drug delivery: A shift in the “ouzo region” upon drug loading

Cited by 181 publications

References 34 publications

Development of biodegradable polymeric nanoparticles for encapsulation, delivery, and improved antifungal performance of natamycin

Development of biodegradable polymeric nanoparticles for encapsulation, delivery, and improved antifungal performance of natamycin

Transport of digoxin-loaded Polymeric Nanoparticles Across BeWo cells, an In Vitro Model of Human Placental Trophoblast

Semi-Automated Nanoprecipitation-System—An Option for Operator Independent, Scalable and Size Adjustable Nanoparticle Synthesis

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