Preparation of nanostructure bioactive diopside scaffolds for bone tissue engineering by two near net shape manufacturing techniques

Ghomi, Hamed; Emadi, Rahmatollah; Javanmard, Shaghayegh Haghjooye

doi:10.1016/j.matlet.2015.12.161

Cited by 23 publications

(12 citation statements)

References 25 publications

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“…Ghomi et al . 36 synthesized nanodiopside by a sol-gel method dissolving Ca(NO 3 ) 2 ·4H 2 O, MgCl 2 ·6H 2 O and TEOS in ethanol which was stirred to form a solution. The dried gel was then calcined for 2 h at 800 °C and then milled for 10 h. The nanoparticles formed were less than 50 nm in diameter.…”

Section: Previous Workmentioning

confidence: 99%

Facile emulsion mediated synthesis of phase-pure diopside nanoparticles

Rodriguez

Anovitz

Clement

et al. 2018

Sci Rep

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Diopside is a common natural pyroxene that is rarely found in a pure state, since magnesium is often partially substituted by iron, and other elements (sodium and aluminum) are often present. This pyroxene, along with feldspars and olivines, is common in concrete. As the prospective license renewal of light water reactors to 80 years of operation has raised concerns on the effects of radiation in the concrete biological shield surrounding the reactors, mineral nanoparticles can be valuable to perform amorphization studies to inform predictive models of mechanical properties of irradiated concrete. The synthesis of diopside nanoparticles was achieved in this study using a reverse-micelle sol-gel method employing TEOS, calcium chloride and Mg(MeO)2 in a methanol/toluene solution. Tert-butylamine and water were used as hydrolysis agents, and dodecylamine as a surfactant. The resulting amorphous precursor was centrifuged to remove organics and fired at 800 °C. Additional reaction with hydrogen peroxide was used to remove amine remnants. TEM and SEM examinations revealed a product comprised of 50–100 nm diameter nanoparticles. XRD indicated phase pure diopside and BET indicated a surface area of 63.5 m2/g before peroxide treatment, which at a bulk density of 3.4 g/cm3 is equivalent to particles with diameter of 28 nm.

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Section: Previous Workmentioning

confidence: 99%

Facile emulsion mediated synthesis of phase-pure diopside nanoparticles

Rodriguez

Anovitz

Clement

et al. 2018

Sci Rep

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“…Therefore, the membrane can be used as the anti-adhesion membranes. Furthermore, the improved pore interconnectivity and the surface area of the membranes will increase the degradation [23] of the membranes.…”

Section: Resultsmentioning

confidence: 99%

A convenient method to fabricate porous cross-linked PCL membrane by using dual pore-forming agents

Yin

Zhang

2016

Materials Letters

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“…The porosities of various SiCa and composite scaffolds have been measured using the aforementioned methods: liquid displacement (distilled water), [ 33,49,50,59,67,68,70,71,74,88–120 ] liquid displacement (ethanol), [ 121–125 ] liquid displacement (hexane), [ 126–129 ] liquid displacement (kerosene), [ 130 ] mercury intrusion, [ 131–135 ] gravimetry [ 45,65,110,136–138 ] , μ‐CT, [ 114,116,139–145 ] 1, and SEM [ 75,84,85,143,146–150 ] according to the literature.…”

Section: Methods To Measure the Porosity Of Porous Scaffoldsmentioning

confidence: 99%

How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

et al. 2021

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Despite progresses in tissue healing, repairing large bone defects remains an unmet challenge. Tissue engineering (TE) using porous scaffolds offers great promise in providing solutions by which bone healing can be increased, and the need for further surgical intervention can be reduced. Nonetheless, the successful performance of a porous scaffold depends on key structural factors including porosity, pore size, geometry, and interconnectivity. Herein, recent advancements on this topic are reviewed and the effects of fabrication methods on making potential scaffolds for advanced bone regeneration are discussed.The upward trend of population aging, increased numbers of accidents, sport injuries, trauma, and bone tumor resection are increasing the demand for substitutes to regenerate and/or repair damaged skeletal and dental bones. [1] Bone tissue poses a simple yet highly organized ultracomposition in which each portion plays a pivotal role in moderating the elasticity and strength of the bone. [2] The intrinsically dynamic bone tissue structure allows the restoration of damaged parts via the self-healing process. [3] This remodeling process is dependent on the dynamic equilibrium between the bone-forming (osteoblast) and bone-resorbing cells (osteoclast) during mechanical stimulation. [4] Nevertheless, this healing process is not sufficient for repairing massive and critical bone defects; thus, there is a need for drastic healing accelerators and substitutive or supportive therapeutics. [5] Specially, the regenerating of large bone defects is a serious and challenging clinical issue. To address the issue, different types of bone graft substitutes such as autografts, allografts, and xenografts are used. [6] These grafts, however, come with certain drawbacks, including donor site morbidity and limited supply. Moreover, aged persons cannot provide rich bone tissue for their own tissue replacement due to osteoporosis. [7] To address the limitations associated with natural bone-derived substitutes, biomaterials have been developed during recent decades. [8] Engineering biomaterials made it possible to simulate the bone microenvironment and construct programmable scaffolds for purposeful therapeutic procedures. Bioactive ceramic materials are favorable for bone tissue engineering (BTE) due to their resemblance to the mineral phase of bone, and direct bonding with host bone tissue without the formation of fibrous tissue. In addition, the variety in the chemical composition of bioceramics, particularly silicate-based ceramics (SiCa), can contribute to adjustments in mechanical properties, bioactivity, and biodegradability.A fundamental constituent of engineering tissue is the scaffold, which acts as the structural template providing a suitable substrate for cell proliferation, differentiation, and attachment resulting in new tissue formation. In tissue engineering (TE), the scaffold serves as the structural guide and the substrate for cell anchorage. The scaffold also contributes to the remodeling of the extracellular mat...

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Preparation of nanostructure bioactive diopside scaffolds for bone tissue engineering by two near net shape manufacturing techniques

Cited by 23 publications

References 25 publications

Facile emulsion mediated synthesis of phase-pure diopside nanoparticles

Facile emulsion mediated synthesis of phase-pure diopside nanoparticles

A convenient method to fabricate porous cross-linked PCL membrane by using dual pore-forming agents

How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

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