Preparation of no-carrier added 16-131I-hexadecanoic acid via halogen exchange: Comparison between two methods

Chemical and Thermodynamic Characteristics of the Isotopic Exchange Reaction between Radioiodine and Iodohippuric Acid Isomers

“…10 The radioiodination of sodium iodohippurate, or hippuric acid isomers, by the isotopic exchange reaction between the substrate and Na*I exchange isotopes leads to the formation of other labeling products e.g., glycyl-o-iodohippurate (g-o-IHA) and o-iodobenzoic acid (o-IBA). [11][12][13][14][15][16][17][18][19] Thus the mechanism of the isotopic exchange reaction between the iodohippurate isomers and radioiodine (as iodide, *I -) in the molten state (160 -170˚C) with no-carrier added (nca) is of great importance. [19][20][21] The goal of the present study was focused on the application of the no-carrier added (nca) radioiodine, 125 I -in molten ammonium acetate (m.p.…”