Preparation of novel antimicrobial polymer colloids based on (+)-usnic acid and poly(vinylbenzyl chloride)

Karabacak, R. Bengü; Tay, Turgay; Kıvanç, Merih

doi:10.1016/j.reactfunctpolym.2014.07.002

Cited by 14 publications

(12 citation statements)

References 27 publications

(39 reference statements)

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“…The toxic and other detrimental influences of gyrophoric acid at high doses (≥400 μM) might limit use in the cosmetic industry in agreement with the previous thought (Nguyen et al , ). However, to upgrade the cosmetic potency of gyrophoric acid, the production of lichen substance loaded composite materials might be an alternative way, allowing lichen substances to have less harmful and more photoprotective effects on human cells, as previously achieved in other areas (Karabacak et al , ). Nevertheless, vulpinic acid seems to be a promising UVB protectant with perfect preventative activity against cytotoxic, apoptotic and cytoskeleton alterative effects of 2.5 J/cm 2 UVB, without the destructive influence on non‐irradiated human keratinocytes for short‐term treatment (120 min).…”

Section: Discussionmentioning

confidence: 97%

Photoprotective Activity of Vulpinic and Gyrophoric Acids Toward Ultraviolet B-Induced Damage in Human Keratinocytes

et al. 2015

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Vulpinic and gyrophoric acids are known as ultraviolet filters for natural lichen populations because of their chemical structures. However, to the best of our knowledge, there has been no reference to their cosmetic potential for skin protection against ultraviolet B (UVB)‐induced damage and, consequently, we propose to highlight their photoprotective profiles in human keratinocytes (HaCaT). Therefore, vulpinic acid and gyrophoric acid were isolated from acetone extracts of Letharia vulpina and Xanthoparmelia pokornyi, respectively. Their photoprotective activities on irradiated HaCaT cells and destructive effects on non‐irradiated HaCaT cells were compared through in vitro experimentation: 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide and lactate dehydrogenase assays, 4′,6‐diamino‐2‐phenylindole and tetramethylrhodamine B isothiocyanate‐phalloidin staining protocols. Both of the lichen substances effectively prevented cytotoxic, apoptotic and cytoskeleton alterative activities of 2.5 J/cm2 UVB in a dose‐dependent manner. Moreover, vulpinic and gyrophoric acids showed no toxic, apoptotic or cytoskeleton alterative effects on non‐irradiated HaCaT cells, except at high doses (≥400 μM) of gyrophoric acid. The findings suggest that vulpinic and gyrophoric acids can be promising cosmetic ingredients to photo‐protect human skin cells and should therefore be further investigated by in vitro and in vivo multiple bioassays. Copyright © 2015 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 97%

Photoprotective Activity of Vulpinic and Gyrophoric Acids Toward Ultraviolet B-Induced Damage in Human Keratinocytes

et al. 2015

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“…18 Several drug delivery systems have been devised for delivering UA. These drug delivery systems include microcapsules 19,20 and nanocapsules, 18 polymer colloids, 21 nanofluids, 22 magnetic nanoparticles, 15,23 etc. Encapsulation of UA in these polymeric vehicles enables the drug to take advantage of their controlled release properties.…”

Section: Introductionmentioning

confidence: 99%

“…24 Poly(vinylbenzyl chloride) based antimicrobial polymer colloids have been synthesized to enable uniform dispersion of UA and, thereby, increase bactericidal activity. 21 Core/shell nanoparticle systems with Fe 3 O 4 /oleic acid/UA have been reported to prevent biofilm formation by S. aureus. 22 The low solubility of the drug typically makes high drug loading a challenge.…”

Section: Introductionmentioning

confidence: 99%

Controlled Release of Usnic Acid from Biodegradable Polyesters to Inhibit Biofilm Formation

Dasgupta

Madras

Chatterjee

2017

ACS Biomater. Sci. Eng.

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Controlled and sustained release of antibacterial drugs is a promising approach to address challenges related to bacterial infections in biomedical implants. Biocompatible polyols like xylitol and mannitol are frequently used to synthesize cross-linked, biodegradable polyesters. Xylitol-based adipoyl and sebacoyl polyesters were synthesized by a catalyst free melt polyesterification technique. Unlike traditional drug delivery systems, the objective of this work was to develop biodegradable polymers with usnic acid (UA), a known antibacterial agent, entrapped in the polymer network. Apart from offering a wider control of the release kinetics and improved processability, the hydrolytic degradation results in the concomitant resorption of the polymer. Polymer properties such as degradation, modulus, and drug release were tuned through a subtle change in the chain length of the diacid. In 1 week, the xylitol based adipoyl ester degrades 41% and releases 25% of its initial drug loading whereas the sebacoyl ester degrades 23% in and releases 9% of the loaded drug. A kinetic model has been used to understand the UA release profiles and determine degradation and release parameters that influence release from the polymers. These polyesters are cytocompatible and exhibit excellent bactericidal activity against Staphyloccus aureus by inducing oxidative stress. This work enables a strategy to synthesize biodegradable polymers for potential to inhibit biofilm formation in vivo with tunable mechanical and degradation properties, and variable controlled release.

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“…A number of polymer-based DDSs have been devised for delivering usnic acid [25][26][27][28][29]. However, this review will focus only on the polymeric nano-and microcarriers (i.e., micro and nanospheres (matrix and capsules), as well as nonspherical nanoparticles (nanofibers)) as systems developed with the aim of achieving maximum tissue compatibility and minimal cytotoxicity [13,30].…”

Section: Polymeric Nano-and Microcarriersmentioning

confidence: 99%

Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of Literature

2020

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Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed hepatotoxicity, have discouraged wide-range utilization of usnic acid as a promising therapeutic agent. In accordance with the growing research interest in the development of nanotechnology, especially in the arena of preparations based on natural sources of medicinal compounds, usnic acid incorporated into nano- and microsized colloidal carriers has been a subject of a large number of publications. Therefore, this review discusses the overall results of the studies dealing with usnic acid encapsulated into lipid-based, polymeric and nonorganic micro- and/or nanocarriers, as potential drug delivery systems for this natural compound, in an attempt to introduce its usage as a potential antitumor, antimicrobial, wound-healing, antioxidative and anti-inflammatory drug.

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Preparation of novel antimicrobial polymer colloids based on (+)-usnic acid and poly(vinylbenzyl chloride)

Cited by 14 publications

References 27 publications

Photoprotective Activity of Vulpinic and Gyrophoric Acids Toward Ultraviolet B-Induced Damage in Human Keratinocytes

Photoprotective Activity of Vulpinic and Gyrophoric Acids Toward Ultraviolet B-Induced Damage in Human Keratinocytes

Controlled Release of Usnic Acid from Biodegradable Polyesters to Inhibit Biofilm Formation

Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of Literature

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