Preparation of novel azidopyrazole derivatives with anticipated cytotoxic and antimicrobial activities

Abstract

The reactions of azidopyrazole with some of primary amines and active methylene compounds were studied. Structures of the prepared compounds were identified using spectroscopic techniques. The reactions mechanisms were also proposed. The cytotoxic and antimicrobial activities were also examined for the newly synthesized compounds.

Synthesis and Antimicrobial Evaluation of New 5-Amino-2,3-dihydrophthalazine-1,4-dione Derivatives

“…[19][20][21][22][23][24][25] So, in this work, we try to synthesize some new compounds that may have antimicrobial activity starting from Luminol with consideration of our experience in the synthesis of new organophosphorus and heterocyclic compounds. [26][27][28][29][30][31] Herein we studied the reactions of 5-amino-2,3dihydrophthalazine-1,4-dione (Luminol 1) with organophosphorus reagents, namely phosphonium ylides (2a-e), trialkyl phosphites (3a-c), tris(dialkylamino)phosphines (3d,e), thiating agents as Lawesson, and Japanese reagents (4a,b) to synthesize a series of phthalazine derivatives and evaluate their antimicrobial activities against some bacterial and fungal strains (Figure 2).…”

Synthesis and evaluation of a new series of spiro aryl dioxolane compounds: A new scaffold as potential poly(ADP‐ribose)polymerase‐1 (PARP‐1) inhibitors

“…In addition, chalcone or benzylideneacetophenone derivatives are the essential constituents of several natural sources and possess numerous biological as well as pharmacological activities [24][25][26][27][28][29][30][31]. Based on the previous findings and as a continuation in the synthesis of some heterocyclic derivatives [32,33], different spiroaryl [1,3]dioxolane compounds were designed, synthesized, and tested as a novel scaffold that could cause potential PARP-1 inhibition (Figure 1).…”