Preparation of Novel Silica Nanoparticles with Controllable Fluorescence Intensity from Porphyrin‐Bridged Silsesquioxane

Abstract

A method for the fabrication of an improved class of controllable fluorescence intensity, highly sensitive and photostable porphyrin doped silica nanoparticles (PDSNPs) was demonstrated. The fluorescence intensity of PDSNPs could be controlled by finely tuning self-dissociated time of the precursor of porphyrin-bridged silsesquioxane. Porphyrin was well dispersed into the silica matrix due to the covalent attachment in the system, thus entirely avoiding the porphyrin leakage and fluorescence quenching effects. The resultant PDSNPs with a narrow size-distributed region and a regular spherical structure can be attained.

Multimodality Imaging of Silica and Silicon Materials In Vivo

“…For instance, in the study of Mader et al surface‐modified silica nanoparticles were linked by means of azide–alkyne click chemistry and in the study of Sen Karaman et al a postsynthesis grafting approach was carried out onto silica nanoparticles with a preprepared fluorescein isothiocyanate (FITC)‐modified aminopropyltriethoxysilane solution. Another approach is the incorporation of already dye‐conjugated silane precursors into the synthesis solution, which is also frequently used in order to covalently link dye molecules into the silica matrix with a homogeneous distribution and high stability …”

Nonporous silica nanoparticles for nanomedicine application

“…For example, Mader et al linked dyes to surface-modified silica NPs by means of azide-alkyne click chemistry [182]. Other groups and our group used a dye-silane precursor, with a stable chemical bond between the dye and silane group, to covalently link dyes to silica NPs with high stability [71, 104, 170]. …”

Spherical and rod shaped mesoporous silica nanoparticles for cancer-targeted and photosensitizer delivery in photodynamic therapy

“…Hence, the use of MSNPs as PS carriers can enhance the selectivity of Pors for targeted tissues and consequently increase the PDT efficiency. 21–26…”

“…Hence, the use of MSNPs as PS carriers can enhance the selectivity of Pors for targeted tissues and consequently increase the PDT efficiency. [21][22][23][24][25][26] Recently, we have reported the enhancement of PDT for bladder cancer by using glycosylated Pors as a PS encapsulated in amorphous SiO 2 nanospheres. 27 Encouraged by these results and considering that the morphology of SiO 2 NPs could affect both the biodistribution and cellular uptake 12,14,28 we decided to investigate the effect of particle shape using the same Pors attached to spherical and rod-like MSNPs.…”