Preparation of oleic acid–carboxymethylcellulose sodium composite vesicle and its application in encapsulating nicotinamide

Abstract

Fatty acid vesicles are a kind of natural biological material, which have the advantages of good biocompatibility, low cost and easy self‐assembly in aqueous solution. However, vesicles formed of fatty acids have weak pH stability and thermostability, and poor divalent salt resistance, which limit their applications. In this work, the anionic surfactant sodium oleate and the polysaccharide carboxymethylcellulose sodium were mixed to form composite vesicles in a wide pH range, which can be close to the pH range of the physiological environment. The morphology of the composite vesicles was characterized using transmission electron microscopy and the particle size was determined by dynamic light scattering. Forces and aggregation behavior in the formation of the composite vesicles were investigated using surface tension and Fourier transform infrared observations combined with turbidity measurements. The composite vesicles were used to encapsulate nicotinamide. The encapsulation efficiency and sustained release behavior of nicotinamide loaded in the composite vesicles were evaluated. These results can provide theoretical guidance for the application of drug‐loaded vesicles in cosmetics. © 2021 Society of Industrial Chemistry.

An investigation on the adsorption and removal performance of a carboxymethylcellulose-based 4-aminophenazone@MWCNT nanocomposite against crystal violet and brilliant green dyes

“…A new curve at 1310 cm −1 representing the ester group was observed. 37,38 A-PH-CMC/MWCNTs cause the aromatic ring of A-PH-CMC to have C]C stretching vibrations between 1440 and 1503 cm −1 , and the covalent coupling with the amine was proven by the appearance of two additional intense bands at about 1662 and 1551 cm −1 attributable to the amide. Moreover, in the A-PH-CMC/MWCNT nanocomposites, absorptions at 2950 cm −1 and 2850 cm −1 were related to C-H stretch modes.…”

Continuous production of nanoemulsion for skincare product using a 3D-printed rotor-stator hydrodynamic cavitation reactor

“…In general, a slightly basic pH of 7.4 does not dry out the skin and is suitable for frequent grooming. Therefore, topical treatments should have a pH value in this range [55] , [74] . The final pH of the skincare lotion was 7.4 under the recommended conditions.…”

Self-Assembly of Palmitic Acid in the Presence of Choline Hydroxide

“…Generally, fatty acids dispersed in alkaline aqueous solution at a specific temperature self-assemble into various aggregates, including micelles, vesicles, or lamellar phases, and oil droplets, depending on pH [2,3,5,[10][11][12][13][14][15][16][17][18]. Different aggregates impart distinct properties to them, and they are extensively employed in fields such as food [19], medicine [9,20], cosmetics [21], chemical engineering [22,23], and primitive membrane models [8,10].…”