2012
DOI: 10.1007/s12257-011-0241-1
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Preparation of peptide-loaded polymer microparticles using supercritical carbon dioxide

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Cited by 11 publications
(10 citation statements)
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“…iii) Particles from Gas Saturated Solutions (PGSS): is a process similar to RESS but in this case the substances are not soluble in the supercritical fluid but they are melted forming a dispersion; then, the Joule-Thomsom effect associated to depressurization cools the dispersion and small particles are obtained 115 . iv) Aerosol solvent extraction system (ASES): drug and polymer are dissolved or dispersed in an organic solvent which is sprayed into a supercritical phase; the organic solvent, soluble in the supercritical gas phase, is extracted resulting in the formation of solid microparticles of drug+polymer 116 .…”
Section: Pharmaceuticalmentioning
confidence: 99%
“…iii) Particles from Gas Saturated Solutions (PGSS): is a process similar to RESS but in this case the substances are not soluble in the supercritical fluid but they are melted forming a dispersion; then, the Joule-Thomsom effect associated to depressurization cools the dispersion and small particles are obtained 115 . iv) Aerosol solvent extraction system (ASES): drug and polymer are dissolved or dispersed in an organic solvent which is sprayed into a supercritical phase; the organic solvent, soluble in the supercritical gas phase, is extracted resulting in the formation of solid microparticles of drug+polymer 116 .…”
Section: Pharmaceuticalmentioning
confidence: 99%
“…Regarding the pharmaceutical field, using the SAS process, up to now, micronized drug particles and several polymer/active compound composites have been proposed for different biomedical applications [31][32][33][34][35]. Indeed, SAS precipitated particles can be used for drug delivery by oral, parenteral, transdermal, or topical routes [2,[36][37][38][39][40][41][42]. The versatile SAS particles can be used in powder form for the oral administration of composites or the preparation of aerosol formulations, mainly for the treatment of respiratory diseases; they can also be used for the production of medicated patches or active topical gels, by incorporating nanoparticles/microparticles into various types of dressings, supports or pomades, respectively.…”
Section: Introductionmentioning
confidence: 99%
“…[34] andLee et al (2008) [35] attempted to enhance the mass transfer of the solute solution and the supercritical fluids phase, known as the SAS-EM process. The SAS-EM process produced quite fine nanoparticles due to the enhancement of the mass transfer effect and relatively high encapsulation efficiencies between 80 and 90%[34, 35].A study conducted byJung et al (2012)…”
mentioning
confidence: 99%