Preparation of peritoneal cell metaphases of rats, mice and chinese hamsters after mitogenic stimulation with magnesium sulfate and/or aluminum hydroxide

Nashed, N.

doi:10.1016/0027-5107(75)90379-6

Cited by 2 publications

(3 citation statements)

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“…Our results as well as the reports from the literature [Nashed, 1975;Jones et al, 1986;Quarles et al, 1991;Carlisle and Curran, 19931 suggest that aluminum may be an essential element for the promotion of optimal growth, development, and maintenance of cells. Further research will confirm this hypothesis.…”

Section: Discussionsupporting

confidence: 85%

“…To our knowledge, this is the first time that a positive effect for aluminum chloride has been observed in human material, although similar stirnulatory effects of aluminum chloride, sulfate, and hydroxide have been reported in nonhuman cells [Jones et al, 1986;Nashed, 1975;Quarles et al, 19911. Our optimal concentrations appeared to be about 2 pM for the alumi-num ion.…”

Section: Discussionmentioning

confidence: 67%

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Effect of aluminum chloride on mitogenesis, mitosis, and cell cycle in human short‐term whole blood cultures: Lower concentrations enhance mitosis

Yao

Jenkins

Wı́sniewski

1994

J of Cellular Biochemistry

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Aluminum, the third most common element in the earth's crust (second to oxygen and silicon) and recently suspected by some investigators to be implicated in Alzheimer disease etiology, has been studied in relation to its effect on mitogenesis, mitosis, and cell cycle. We have observed that 2-4 mM concentrations of AlCl3 have decreased the number of cells that undergo mitogenesis (PHA-induced blast transformation) and mitosis in human short term whole blood cultures. We have also shown that the rate of the cell cycle was slowed down, i.e., cell cycle time was increased in the presence of AlCl3. Also, we have demonstrated a reversible effect on aluminum-induced reduced mitotic index in long-term EBV-transformed lymphoblastoid cultures. Although safeguards such as limiting aluminum serum concentrations have been recommended to protect individuals undergoing dialysis, it should be realized that concentration accumulations of aluminum may increase over chronic exposures. Accordingly, if the number of cells stimulated by PHA is reduced in the presence of AlCl3, there may be a reduction of immune competence, since the degree of PHA stimulation has been used as an indicator of immune response. Similar reductions in mitotic index could affect every tissue involved with cell division. Although it may not be the same for higher concentrations, from our results, we have also shown that decreased mitotic rates were reversible in long-term EBV-transformed lymphoblastoid cultures. Increased numbers of mitoses were observed in human short-term whole blood cultures that were exposed to 2 microM concentrations of aluminum chloride.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 67%

Effect of aluminum chloride on mitogenesis, mitosis, and cell cycle in human short‐term whole blood cultures: Lower concentrations enhance mitosis

Yao

Jenkins

Wı́sniewski

1994

J of Cellular Biochemistry

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“…In common with other agents producing protein: DNA cross-linking, Al 3+ has however been demonstrated to be clastogenic in vitro and in vivo and to decrease cell division both in mammalian and plant cells. Chromosomal aberrations have been reported in peritoneal lavage cells obtained from rats, mice and Chinese hamsters exposed in vitro to aluminium hydroxide (Nashed, 1975as reported in Bhamra & Costa, 1992, and WHO, 1997. In an early study, cultured human blood lymphocytes treated with 20 μg/ml aluminium sulphate showed positive responses for induction of micronuclei, chromatid type aberrations and sister chromatid exchanges (Roy et al, 1990).…”

Section: Genotoxicitymentioning

confidence: 88%

Safety of aluminium from dietary intake ‐ Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC)

2008

EFS2

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Following a request from the Commission, the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC) was asked to provide a scientific opinion on the safety of aluminium from all sources of dietary intake. In the event the estimated exposure for a particular sub-group(s) is found to exceed the Provisional Tolerable Weekly Intake, a detailed breakdown by exposure source should be provided. Aluminium occurs naturally in the environment and is also released due to anthropogenic activities such as mining and industrial uses, in the production of aluminium metal and other aluminium compounds. A variety of aluminium compounds are produced and used for different purposes, such as in water treatment, papermaking, fire retardant, fillers, food additives, colours and pharmaceuticals. Aluminium metal, mainly in the form of alloys with other metals, has many uses including in consumer appliances, food packaging and cookware. The major route of exposure to aluminium for the general population is through food. Aluminium in drinking water represents another, minor, source of exposure. Additional exposures may arise from the use of aluminium compounds in pharmaceuticals and consumer products. Most unprocessed foods typically contain less than 5 mg aluminium/kg. Higher concentrations (mean levels 5 to 10 mg/kg) were often found in breads, cakes and pastries (with biscuits having the highest levels), some vegetables (with mushrooms, spinach, radish, swiss card, 1 For citation purposes: Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials on a request from European Commission on Safety of aluminium from dietary intake.

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Preparation of peritoneal cell metaphases of rats, mice and chinese hamsters after mitogenic stimulation with magnesium sulfate and/or aluminum hydroxide

Cited by 2 publications

References 0 publications

Effect of aluminum chloride on mitogenesis, mitosis, and cell cycle in human short‐term whole blood cultures: Lower concentrations enhance mitosis

Effect of aluminum chloride on mitogenesis, mitosis, and cell cycle in human short‐term whole blood cultures: Lower concentrations enhance mitosis

Safety of aluminium from dietary intake ‐ Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC)

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