Preparation of pH-sensitive chitosan-deoxycholic acid-sodium alginate nanoparticles loaded with ginsenoside Rb1 and its controlled release mechanism

Dong, Yujia; He, Yanhui; Fan, Daidi; Wu, Zhansheng

doi:10.1016/j.ijbiomac.2023.123736

Cited by 9 publications

(1 citation statement)

References 32 publications

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“…Furthermore, Dong et al engineered CDA-NPs through the ionic cross-linking of CS with hydrophobic deoxycholic acid, creating an effective loading environment for hydrophobic GRb1. These NPs, which improved the stability, oral bioavailability and absorption efficiency of GRb1, exhibited notable pH sensitivity and controlled release capabilities, leading to sustained release profiles in simulated gastric fluid, making them an ideal oral delivery system for managing gastrointestinal disorders (Dong et al, 2023).…”

Section: Ginsenosidesmentioning

confidence: 99%

The development of nanocarriers for natural products

Huang,

Luo,

Tong

et al. 2024

WIREs Nanomed Nanobiotechnol

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Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant bioactive compounds is hindered by low solubility and instability. Conventional pharmaceutical forms, such as tablets and capsules, only partially overcome these limitations, restricting their efficacy. With the recent development of nanotechnology, nanocarriers can enhance the bioavailability, stability, and precise intracellular transport of plant bioactive compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into the development of natural plant compounds with significant success. Moreover, natural products benefit from nanotechnological enhancement and contribute to the innovation and optimization of nanocarriers via self‐assembly, grafting modifications, and biomimetic designs. This review aims to elucidate the collaborative and reciprocal advancement achieved by integrating nanocarriers with botanical products, such as bioactive compounds, polysaccharides, proteins, and extracellular vesicles. This review underscores the salient challenges in nanomedicine, encompassing long‐term safety evaluations of nanomedicine formulations, precise targeting mechanisms, biodistribution complexities, and hurdles in clinical translation. Further, this study provides new perspectives to leverage nanotechnology in promoting the development and optimization of natural plant products for nanomedical applications and guiding the progression of NDDS toward enhanced efficiency, precision, and safety.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Section: Ginsenosidesmentioning

confidence: 99%