Preparation of pH-sensitive chitosan/polyvinylpyrrolidone/α-Fe2O3 nanocomposite for drug delivery application: Emphasis on ameliorating restrictions

Gerami, Saman Emami; Pourmadadi, Mehrab; Fatoorehchi, Hooman; Yazdian, Fatemeh; Rashedi, Hamid; Navaei-Nigjeh, Mona

doi:10.1016/j.ijbiomac.2021.01.067

Cited by 106 publications

(37 citation statements)

References 58 publications

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“…The peak at 887 cm −1 is assigned to out-of-plane bending of the C–H bond of the monosaccharide ring. The peaks appearing at 1020 cm −1 and 1060 cm −1 can be assigned to tensile vibration of the C–O bond, in agreement with the spectra recorded in previous articles [ 90 , 91 , 92 , 93 , 94 ]. The peak near 1320 cm −1 is attributed to the C–N tensile vibration of the ternary amide bond, which is consistent with the results from other articles [ 95 ].…”

Section: Resultssupporting

confidence: 91%

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

et al. 2022

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Today, cancer treatment is an important issue in the medical world due to the challenges and side effects of ongoing treatment procedures. Current methods can be replaced with targeted nano-drug delivery systems to overcome such side effects. In the present work, an intelligent nano-system consisting of Chitosan (Ch)/Gamma alumina (γAl)/Fe3O4 and 5-Fluorouracil (5-FU) was synthesized and designed for the first time in order to influence the Michigan Cancer Foundation-7 (MCF-7) cell line in the treatment of breast cancer. Physico-chemical characterization of the nanocarriers was carried out using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), dynamic light scattering (DLS), and scanning electron microscopy (SEM). SEM analysis revealed smooth and homogeneous spherical nanoparticles. The high stability of the nanoparticles and their narrow size distribution was confirmed by DLS. The results of the loading study demonstrated that these nano-systems cause controlled, stable, and pH-sensitive release in cancerous environments with an inactive targeting mechanism. Finally, the results of MTT and flow cytometry tests indicated that this nano-system increased the rate of apoptosis induction on cancerous masses and could be an effective alternative to current treatments.

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Section: Resultssupporting

confidence: 91%

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

et al. 2022

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“…Materials with high magnetism such as pure metals (e.g., cobalt, nickel, and iron), alloys (e.g., CoPt and FePt), and metal oxides (e.g., Fe 3 O 4 , Co 3 O 4 , and NiO) have the potential to be produced as magnetic nanoparticles (MNPs). , Iron oxides such as magnetite (Fe 3 O 4 ) and maghemite (γ-Fe 2 O 3 ) are some of the most studied MNPs because of their high chemical stability, biocompatibility, and low cost. , They have been applied as diagnostic [e.g., as a contrast agent for magnetic resonance imaging (MRI)] and therapeutic (e.g., drug delivery and hyperthermia) agents. − In addition, the strong reducing property, high surface-to-volume ratio, and surface modification allow utilization of these materials as nanosorbents and photocatalysts. , Iron oxide MNPs have been incorporated in various polymeric matrices and other materials to produce magnetic nanocomposites (MNCs). − This class of materials has shown potential in various applications such as sensors, cancer therapy, drug delivery, anticounterfeiting materials, anticorrosion coatings, flame retardants, and UV protectors …”

Section: Introductionmentioning

confidence: 99%

“…12,13 Iron oxide MNPs have been incorporated in various polymeric matrices and other materials to produce magnetic nanocomposites (MNCs). 14−22 This class of materials has shown potential in various applications such as sensors, 16 cancer therapy, 17 drug delivery, 18 anticounterfeiting materials, 19 anticorrosion coatings, 20 flame retardants, 21 and UV protectors. 22 Recently, the fabrication and use of PDA/Fe 3 O 4 -MNCs have been explored.…”

Section: Introductionmentioning

confidence: 99%

ZnFe₂O₄ Magnetic Nanoparticle–Polydiacetylene–Zinc(II) Composites for Real-Time Nanothermometers and Localizable Acid/Base Sensors

Kingchok

Nontasorn

Laohhasurayotin

et al. 2021

ACS Appl. Nano Mater.

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Nanocomposites of polydiacetylene (PDA) and magnetic nanoparticles (MNPs), exhibiting irreversible thermochromism, have shown potential for use as nanothermometers. This type of nanocomposite, however, does not allow measurement of the real-time temperature. In this study, we introduce the first example of magnetic PDA-based nanocomposites, exhibiting reversible thermochromism and colorimetric response to both acidic and basic conditions. Zinc ferrite magnetic nanoparticles (ZnFe2O4-MNPs) decorated the surface of PDA/Zn2+ assemblies, forming PDA/Zn2+/ZnFe2O4 magnetic nanocomposites. The intercalation of Zn2+ ions, released from ZnFe2O4-MNPs, with PDA bilayers via strong interaction with a carboxylate headgroup provides reversible thermochromism. This reversible thermochromic nanocomposite with magnetic properties is ideally suited for advanced applications requiring precise local thermal or pH sensing. For instance, the magnetothermally induced thermochromism of PDA could be implemented for real-time measurement of the local temperature (e.g., magnetic hyperthermia), visualization of the magnetic field, and many other related applications. In addition, the colorimetric response of this material to acids and bases makes possible measurement of the local pH in a small-scale environment, localized at a target area, focused using an external magnetic field.

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“…Many biosafe and biodegradable materials have been utilized as nanocarriers to prepare the nanodelivery system for NRG, in particular, chitosan [21,22], cyclodextrin [23,24], polylactic acid [25,26], polylactic acid/glycolic acid copolymer [27,28], polycaprolactone [29,30], poly(vinylpyrrolidone) [31], and tocopheryl polyethylene glycol succinate (TPGS) [32,33]. Among them, TPGS has been utilized broadly as a nanocarrier to encapsulate NRG, because of its excellent amphiphilic properties, entrapment efficacy, and biosafety [34,35].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Naringenin Nanoparticles to Improve the Antitussive Effects on Post-Infectious Cough

Dong

Wang

et al. 2022

Molecules

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Naringenin (NRG) is a natural compound with several biological activities; however, its bioavailability is limited owing to poor aqueous solubility. In this study, NRG nanoparticles (NPs) were prepared using the wet media milling method. To obtain NRG NPs with a small particle size and high drug-loading content, the preparation conditions, including stirring time, temperature, stirring speed, and milling media amount, were optimized. The NRG (30 mg) and D-α-tocopherol polyethylene glycol succinate (10 mg) were wet-milled in deionized water (2 mL) with 10 g of zirconia beads via stirring at 50 °C for 2 h at a stirring speed of 300 rpm. As a result, the NRG NPs, with sheet-like morphology and a diameter of approximately 182.2 nm, were successfully prepared. The NRG NPs were stable in the gastrointestinal system and were released effectively after entering the blood circulation. In vivo experiments indicated that the NRG NPs have good antitussive effects. The cough inhibition rate after the administration of the NRG NPs was 66.7%, cough frequency was three times lower, and the potential period was 1.8 times longer than that in the blank model group. In addition, the enzyme biomarkers and histological analysis results revealed that the NRG NPs can effectively regulate the inflammatory and oxidative stress response. In conclusion, the NRG NPs exhibited good oral bioavailability and promoted antitussive and anti-inflammatory effects.

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Preparation of pH-sensitive chitosan/polyvinylpyrrolidone/α-Fe2O3 nanocomposite for drug delivery application: Emphasis on ameliorating restrictions

Cited by 106 publications

References 58 publications

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

ZnFe₂O₄ Magnetic Nanoparticle–Polydiacetylene–Zinc(II) Composites for Real-Time Nanothermometers and Localizable Acid/Base Sensors

Optimization of Naringenin Nanoparticles to Improve the Antitussive Effects on Post-Infectious Cough

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Preparation of pH-sensitive chitosan/polyvinylpyrrolidone/α-Fe2O3 nanocomposite for drug delivery application: Emphasis on ameliorating restrictions

Cited by 106 publications

References 58 publications

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

ZnFe2O4 Magnetic Nanoparticle–Polydiacetylene–Zinc(II) Composites for Real-Time Nanothermometers and Localizable Acid/Base Sensors

Optimization of Naringenin Nanoparticles to Improve the Antitussive Effects on Post-Infectious Cough

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Product

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ZnFe₂O₄ Magnetic Nanoparticle–Polydiacetylene–Zinc(II) Composites for Real-Time Nanothermometers and Localizable Acid/Base Sensors