Preparation of Photopolymerizable HEMA/PEG-DA Based Hydrogels Filled with Low Concentrations of Nanoparticle Titanium Dioxide for Release Of Donepezil HCl

Abstract

2-hydroxyl ethyl methacrylate/poly(ethylene glycol) diacrylate (HEMA/PEG-DA) based hydrogels are attractive drug carriers due to their appealing properties such as biodegradability and sustained release. The scope of this study was to investigate the swelling and release behaviors of HEMA/PEG-DA-based hydrogels filled with low concentrations of nanoparticle titanium dioxide (TiO 2 ). Hydrogels have been synthesized successfully by photopolymerization. 2,2-dimethoxy-2-phenyl-acetophenone (Irgacure 651), 1hydroxycyclohexyl phenyl ketone (Irgacure 184) and 2-hydroxy-4'-(2-hydroxyethoxy)-2 methylpropiophenone (Irgacure 2959) were selected for photopolymerization. Fourier Transform Infrared Spectroscopy (FT-IR) had been used in confirming the functional group of hydrogels. A digital microscope and Scanning Electron Microscope (SEM) were used for characterizing synthesized hydrogels. This study revealed that the content of hydrogels, the kind of photo-initiators and pH have a significant effect on the swelling and releasing of Donepezil Hydrochloride (active pharmaceutical ingredient (API) for Alzheimer disease) behaviours.

Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration

“…Furthermore, in the production of nanocomposite hydrogel, UV radiation can be used to improve their properties [ 14 ] and has advantages such as low cost, simple equipment, and a fast reaction rate [ 15 ]. Irgacure (IG) is a photoinitiator widely used in this process because it is tolerated by several types of cells and has good efficiency in the production of polymer/clay nanocomposites [ 16 , 17 ].…”