2024
DOI: 10.1002/mabi.202300469
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Preparation of PMMA‐Based Temperature/pH Responsive Nanoparticles Encapsulating 5‐Fluorouracil and Methotrexate In Situ by One‐Pot Dispersion Photopolymerization

Siyuan Yu,
Xian Shao,
Tong Wu
et al.

Abstract: In order to achieve long‐term and controllable release of anti‐tumor drugs at specific sites, temperature/pH responsive nanoparticles encapsulating 5‐fluorouracil (5‐FU) and methotrexate (MTX) in situ were prepared through dispersion photopolymerization under green LED irradiation. The physicochemical properties of nanoparticles were characterized by SEM, FTIR, DLS, TG/DSC and XRD. In vitro drug release at different temperatures and pH values was examined to ascertain the release pattern of two drugs, which ca… Show more

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