Preparation of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) particles in O/W emulsion

Pich, Andrij; Schiemenz, Nadine; Corten, Cathrin; Adler, Hans‐Juergen P.

doi:10.1016/j.polymer.2006.01.038

Cited by 34 publications

(26 citation statements)

References 19 publications

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“…Nanoparticles made from natural polymers are interesting drug delivery systems due to their characteristics of biodegradability and biocompatibility [Pich et al, 2006;Reis et al, 2006;Poletto et al, 2008]. PHBV belongs to the group of polyhydroxyalkanoates (PHAs), polyesters naturally synthesized by microorganisms and deposited intracellularly as insoluble spherical inclusions [Grage et al, 2009].…”

Section: Introductionmentioning

confidence: 99%

“…Due to the thermoreversible gelation of PHBV in toluene, the O/W dispersion was performed by means of ultrasonic agitation with heating (70 o C). Gel beads swollen in toluene were formed after cooling the dispersion to room temperature and the solvent was extracted with ethanol [Pich et al, 2006]. The authors obtained particles with a relatively broad particle size distribution and observed that the particle shape was strongly affected by the ultrasonic power and the mode of toluene extraction.…”

Section: Introductionmentioning

confidence: 99%

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Poly(3-hydroxybutyrate-co-3- hydroxyvalerate) nanoparticles prepared by a miniemulsion/solvent evaporation technique: effect of phbv molar mass and concentration

Leimann

Cardozo‐Filho

Sayer

et al. 2013

Braz. J. Chem. Eng.

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-Miniemulsification and emulsion/solvent evaporation techniques were combined to produce poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles. Those nanoparticles were prepared with different PHBV molar masses and PHBV concentrations to verify their effect on the final particle size. Nanoparticles with an average diameter of 133 nm were obtained when a low molar mass (Mw = 44,350 g/mol) polymer was used. On the other hand, when high molar mass PHBV (Mw = 369,900 g/mol) was used under the same operational conditions, nanoparticles with a 300 nm average diameter and a broader particle size distribution were formed. Results also showed that increasing the PHBV concentration led to an increase of the particle size and, when the polymer/costabilizer (PHBV/hexadecane) weight ratio was close to 1, nanocapsules (hexadecane core surrounded by a PHBV shell) were formed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Poly(3-hydroxybutyrate-co-3- hydroxyvalerate) nanoparticles prepared by a miniemulsion/solvent evaporation technique: effect of phbv molar mass and concentration

Leimann

Cardozo‐Filho

Sayer

et al. 2013

Braz. J. Chem. Eng.

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“…1,2 Among numerous microbial polyesters, poly(3-hydroxybutirate-co-3-hydroxyvalerate) (PHBV) has been widely investigated as a biocompatible material suitable for pharmaceutical and medical applications. The literature reports the use of PHBV in tissue engineering and as drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique

Farago¹,

Raffin²,

Pohlmann³

et al. 2008

J. Braz. Chem. Soc.

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Micropartículas de poli(3-hidroxibutirato-co-3-hidroxivalerato) (PHBV) contendo um fármaco modelo hidrofílico, o cloridrato de metformina (MH), foram obtidas pela técnica de emulsão múltipla/evaporação do solvente. Diversas formulações foram preparadas, com o objetivo de investigar a influência de cada composição sobre a eficiência de encapsulação (EE). O resultado mais elevado de EE (9,76%) foi verificado quando da simultânea alcalinização e adição de NaCl na fase aquosa externa da formulação. O estudo por MEV das micropartículas revelou morfologia esférica e superfície rugosa. As intensidades de difração cristalina para as micropartículas contendo o MH foram menores do que aquelas observadas para a mistura física. Os resultados obtidos por IVTF sugerem que nenhuma ligação química foi formada entre o polímero e o fármaco. A avaliação por análise térmica indica o surgimento de interações favoráveis entre MH e PHBV. O estudo de liberação in vitro demonstrou a influência do PHBV no perfil de dissolução do MH.Poly(3-hydroxybutirate-co-3-hydroxyvalerate) (PHBV) microparticles containing a watersoluble model drug, metformin hydrochloride (MH), were obtained by a double emulsion/solvent evaporation technique. Several formulations were prepared in order to investigate the influence of each composition on the encapsulation efficiency (EE). The highest value of EE (9.76%) was obtained using simultaneously pH alkalinization and NaCl addition in the external water phase of the formulation. SEM study revealed a spherical morphology and a rough surface. The crystalline diffraction intensities for the MH-loaded microparticles were lower than that verified for the physical mixture. FTIR results suggested that no chemical bond between the polymer and the drug was formed. Also thermal analyses indicated a favorable interaction between MH and PHBV. In vitro drug release demonstrated the influence of the PHBV on the dissolution profile of MH. Keywords: PHBV, double emulsion/solvent evaporation technique, hydrophilic model drug, microparticles IntroductionBiodegradable polymeric materials have been received increasing interest due to several ecological and recycling aspects. 1,2 Among numerous microbial polyesters, poly(3-hydroxybutirate-co-3-hydroxyvalerate) (PHBV) has been widely investigated as a biocompatible material suitable for pharmaceutical and medical applications. The literature reports the use of PHBV in tissue engineering and as drug delivery systems. [3][4][5][6][7][8][9][10][11][12] Particularly, PHBV exhibits unique and interesting physicochemical features (e.g. piezoelectricity) in addition to their mechanical properties similar to the polypropylene and other widely used polyesters [e.g. poly(DL-lactide) and poly(DL-lactide-co-glycolide)]. 13 Moreover, PHBV is a less crystalline biopolymer than poly(3-hydroxybutirate), therefore an enhanced degradation rate is observed. 14 Farago et al. 1299 Vol. 19, No. 7, 2008 Several methods have been used to prepare microparticles, for both natural and synthetic polymers. 15...

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“…PHB and PHBV have similar semicrystalline properties with PHB but it also depends on 3-HV content (Fig. 1) [10][11][12].…”

Section: Polyhydroxyalkanoates and Derivativesmentioning

confidence: 99%

“…The melting point of copolymer reduces as the composition of HV increases. Copolymers can be processed by extrusion, injection molding and solution casting methods [10][11][12]14].…”

Section: Polyhydroxyalkanoates and Derivativesmentioning

confidence: 99%

Potential of polyhydroxyalkanoate (PHA) polymers family as substitutes of petroleum based polymers for packaging applications and solutions brought by their composites to form barrier materials

Keskin

Kızıl

Bechelany

et al. 2017

Pure and Applied Chemistry

124

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Today, there is an increasing concern about protection of ecological systems. Petro-based synthetic polymers are not biodegradable and cause environmental pollution. These polymers that are stuck in nature, affect wildlife adversely. Also, in future petrochemical materials will drain away and demand for ecofriendly plastics which can substitute synthetic plastics will increase. Biopolymers are products which can be degraded by enzymatic activities of various microorganisms, and the degradation products are nontoxic. They are attractive alternatives to non-degradable materials in short-term applications such as packaging. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a member of polyhydroxyalkanoate (PHA) family which is biodegradable and produced by microorganism. It has good gas barrier properties that make it convenient to use in different applications. The present paper gives an overview on PHAs and their composites, their main properties, with a specific focus on potential applications of PHBV in packaging.

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Preparation of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) particles in O/W emulsion

Cited by 34 publications

References 19 publications

Poly(3-hydroxybutyrate-co-3- hydroxyvalerate) nanoparticles prepared by a miniemulsion/solvent evaporation technique: effect of phbv molar mass and concentration

Poly(3-hydroxybutyrate-co-3- hydroxyvalerate) nanoparticles prepared by a miniemulsion/solvent evaporation technique: effect of phbv molar mass and concentration

Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique

Potential of polyhydroxyalkanoate (PHA) polymers family as substitutes of petroleum based polymers for packaging applications and solutions brought by their composites to form barrier materials

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