Preparation of Polycaprolactone/Ethanolic Extract Propolis Nanofibers Films

Sutjarittangtham, Krit; Sanpa, Sirikarn; Tunkasiri, Tawee; Rachtanapun, Pornchai; Chantawannakul, Panuwan; Intatha, Uraiwan; Pengpat, Kamonpan; Rujijanagul, Gobwute; Eitssayeam, Sukum

doi:10.4028/www.scientific.net/amr.506.226

Cited by 7 publications

(5 citation statements)

References 18 publications

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“…Sutjarittangtham et al showed that fiber diameters were decreased by the addition of different concentration of Ps. The fiber diameters were decreased from 140-190 nm to 60-70 nm due to higher Ps content [58]. It is also important to mention that when analyzing the surfaces of the strands there are no cracks or defects (such as, especially, micropores in the structure of strands or shrinking of the strands) which could affect the structural integrity, especially when exposed to tensile loading.…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity

Aranci

Uzun

et al. 2020

Molecules

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In this study, the main aim was to fabricate propolis (Ps)-containing wound dressing patches using 3D printing technology. Different combinations and structures of propolis (Ps)-incorporated sodium alginate (SA) scaffolds were developed. The morphological studies showed that the porosity of developed scaffolds was optimized when 20% (v/v) of Ps was added to the solution. The pore sizes decreased by increasing Ps concentration up to a certain level due to its adhesive properties. The mechanical, swelling-degradation (weight loss) behaviors, and Ps release kinetics were highlighted for the scaffold stability. An antimicrobial assay was employed to test and screen antimicrobial behavior of Ps against Escherichia coli and Staphylococcus aureus strains. The results show that the Ps-added scaffolds have an excellent antibacterial activity because of Ps compounds. An in vitro cytotoxicity test was also applied on the scaffold by using the extract method on the human dermal fibroblasts (HFFF2) cell line. The 3D-printed SA–Ps scaffolds are very useful structures for wound dressing applications.

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Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity

Aranci

Uzun

et al. 2020

Molecules

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“…The results indicated that blending propolis with polyurethane led to improved physiochemical and biological characteristics. Similar studies on propolis nanofibers preparation were also reported, but using different polymers such as polyvinyl alcohol [ 92 , 93 ], polycaprolactone [ 94 ], and poly(lactide-co-glycolide) [ 95 ].…”

Section: Current Nanoformulations Of Propolismentioning

confidence: 78%

New insights of propolis nanoformulation and its therapeutic potential in human diseases

Kustiawan,

Syaifie,

Siregar

et al. 2024

ADMET DMPK

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Background and purpose: Scientific research is crucial to develop therapies for various disease severity levels, as modern drugs cause side effects and are difficult to predict. Researchers are exploring herbal alternatives with fewer side effects, particularly propolis, which has been validated through in vitro, in vivo, and clinical studies. This will focus on scientific evidence and its supporting technology for developing new bioactive compounds for chronic diseases. Nanotechnology can improve the delivery and absorption of herbal medicines, which often have poor bioavailability due to their high molecular weight and solubility in water, particularly in oral medicines. This technology can enhance propolis's effects through multi-target therapy and reduce side effects. Experimental approach: All publications related to each section of this review were discovered using the search engines Google Scholar, Scopus, and Pubmed. This was only available for publication between 2013 and 2023. The selected publications were used as references in this review after being thoroughly studied. Key results: Evaluation of propolis active compounds, the classification of propolis nano formulations, design concepts, and mechanisms of action of propolis nano formulation. Additionally, the challenges and prospects for how these insights can be translated into clinical benefits are discussed. Conclusion: In the last ten years, a list of nanoformulation propolis has been reported. This review concludes the difficulties encountered in developing large-scale nanoformulations. To commercialize them, improvements in nano carrier synthesis, standardized evaluation methodology within the framework of strategy process improvement, and Good Manufacturing Practices would be required.

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“…The potential of electrospun PCL for wound healing and skin tissue engineering has recently been comprehensively reviewed, 3 encompassing blending or coating with natural macromolecules such as collagen, gelatin or chitosan, 20 or the incorporation of natural antimicrobials such as curcumin, shikonin or Inula graveolens (L.) 3,21 . PCL has previously been electrospun with ethanolic extract propolis (EEP), 22 in a study that considered the effect of the EEP concentration with respect to fixed electrospinning parameters. Propolis extract from different geographical sources has also been incorporated in other electrospun polymer systems, including polyurethane, polyvinylpyrrolidone (PVP), poly vinyl (alcohol) (PVA), zein and poly(lactide‐co‐glycolide) copolymer (PLGA) 3,23–25 .…”

Section: Introductionmentioning

confidence: 99%

Electrospun poly(e‐caprolactone)/propolis fiber morphology: A process optimisation study

Salimbeigi

Oliveira

McGuinness

2022

J of Applied Polymer Sci

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This study focuses on combining the synthetic polymer poly(Ɛ-caprolactone) with the natural antibacterial propolis, and uses response surface methodology based on a three-level, four-variable Box-Behnken design, to model the dependence of fiber diameter distribution on process parameters. The effect of the concentration of the antibacterial substance, the flow rate, the voltage, and the collector distance were analyzed. The linear coefficients of the antibacterial content and flow rate, and the quadratic coefficients of the voltage, distance and flow rate as well as the interaction effect between voltage and distance were found to be statistically significant. Parameters capable of forming small diameter fibers were targeted for higher surface area to material volume ratios.The parameters predicted to produce a minimum average fiber diameter of 0.506 μm were then validated in a confirmatory experiment giving a 0.505 μm average. The model maps the impact of electrospinning parameters on the fabrication and morphology of PCL/propolis scaffolds, which have potential woundcare applications.

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Preparation of Polycaprolactone/Ethanolic Extract Propolis Nanofibers Films

Cited by 7 publications

References 18 publications

3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity

3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity

New insights of propolis nanoformulation and its therapeutic potential in human diseases

Electrospun poly(e‐caprolactone)/propolis fiber morphology: A process optimisation study

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