Preparation of polycation with hydroxyls for enhanced delivery of miRNA in osteosarcoma therapy

Chen, Dafu; Zhang, Bo-Wen; Cao, Jiyue; Wang, Honggang; Luo, Peng; Liu, Weifeng; Niu, Xiaohui; Wang, Renxian; Nie, Jing‐Jun

doi:10.1039/d2bm00253a

Cited by 3 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 b). Compared with the control group, the addition of chemotherapeutic CDDP could significantly inhibited the viability of K7M2 cells, for that CDDP could binding to DNA in tumor cells and inhibiting its replication [ 46 ]. The viability of osteosarcoma cells in the LPAD/GSDME group was also inhibited.…”

Section: Resultsmentioning

confidence: 99%

Enhanced pyroptosis induction with pore-forming gene delivery for osteosarcoma microenvironment reshaping

Nie,

Zhang,

Luo

et al. 2024

Bioactive Materials

Self Cite

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Enhanced pyroptosis induction with pore-forming gene delivery for osteosarcoma microenvironment reshaping

Nie,

Zhang,

Luo

et al. 2024

Bioactive Materials

Self Cite

View full text Add to dashboard Cite

Localized Nanoparticle‐Mediated Delivery of miR‐29b Normalizes the Dysregulation of Bone Homeostasis Caused by Osteosarcoma whilst Simultaneously Inhibiting Tumor Growth

et al. 2023

View full text Add to dashboard Cite

Patients diagnosed with osteosarcoma undergo extensive surgical intervention and chemotherapy resulting in dismal prognosis and compromised quality of life owing to poor bone regeneration, which is further compromised with chemotherapy delivery. This study aims to investigate if localized delivery of miR‐29b—which is shown to promote bone formation by inducing osteoblast differentiation and also to suppress prostate and cervical tumor growth—can suppress osteosarcoma tumors whilst simultaneously normalizing the dysregulation of bone homeostasis caused by osteosarcoma. Thus, the therapeutic potential of microRNA (miR)‐29b is studied to promote bone remodeling in an orthotopic model of osteosarcoma (rather than in bone defect models using healthy mice), and in the context of chemotherapy, that is clinically relevant. A formulation of miR‐29b:nanoparticles are developed that are delivered via a hyaluronic‐based hydrogel to enable local and sustained release of the therapy and to study the potential of attenuating tumor growth whilst normalizing bone homeostasis. It is found that when miR‐29b is delivered along with systemic chemotherapy, compared to chemotherapy alone, the therapy provided a significant decrease in tumor burden, an increase in mouse survival, and a significant decrease in osteolysis thereby normalizing the dysregulation of bone lysis activity caused by the tumor.

show abstract

Delivery of miRNAs Using Nanoparticles for the Treatment of Osteosarcoma

Wang,

Zhang,

Kong

et al. 2024

IJN

View full text Add to dashboard Cite

Osteosarcoma is the predominant primary malignant bone tumor that poses a significant global health challenge. MicroRNAs (miRNAs) that regulate gene expression are associated with osteosarcoma pathogenesis. Thus, miRNAs are potential therapeutic targets for osteosarcoma. Nanoparticles, widely used for targeted drug delivery, facilitate miRNA-based osteosarcoma treatment. Numerous studies have focused on miRNA delivery using nanoparticles to inhibit the progress of osteosarcoma. Polymer-based, lipid-based, inorganic-based nanoparticles and extracellular vesicles were used to deliver miRNAs for the treatment of osteosarcoma. They can be modified to enhance drug loading and delivery capabilities. Also, miRNA delivery was combined with traditional therapies, for example chemotherapy, to treat osteosarcoma. Consequently, miRNA delivery offers promising therapeutic avenues for osteosarcoma, providing renewed hope for patients. This review emphasizes the studies utilizing nanoparticles for miRNA delivery in osteosarcoma treatment, then introduced and summarized the nanoparticles in detail. And it also discusses the prospects for clinical applications.

show abstract

Preparation of polycation with hydroxyls for enhanced delivery of miRNA in osteosarcoma therapy

Abstract: Osteosarcoma, a malignant bone tumor usually occurs in children and adolescents, has a high rate of death and disability which bringing great pains to society and families. Improving treatment approaches...

Cited by 3 publications

References 32 publications

Enhanced pyroptosis induction with pore-forming gene delivery for osteosarcoma microenvironment reshaping

Enhanced pyroptosis induction with pore-forming gene delivery for osteosarcoma microenvironment reshaping

Localized Nanoparticle‐Mediated Delivery of miR‐29b Normalizes the Dysregulation of Bone Homeostasis Caused by Osteosarcoma whilst Simultaneously Inhibiting Tumor Growth

Delivery of miRNAs Using Nanoparticles for the Treatment of Osteosarcoma

Contact Info

Product

Resources

About