Preparation of polymersomes from synthesized hyaluronic acid-graft-poly(ε-caprolactone) copolymers for drug delivery to the brain

Kiani-Dehkordi, B.; Vatanara, Alireza; Hamidi, Mehrdad; Dibaei, Maryam; Norouzi, Parisa; Rezaei, Seyed Jamal Tabatabaei; Khoshnazar, A.; Rouini, Mohammad-Reza

doi:10.1016/j.mtchem.2023.101504

Cited by 8 publications

(2 citation statements)

References 66 publications

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“…The self-assembly of amphipathic HA into nanogels is driven by hydrophobic interactions, resulting in polymeric micelles in water. A variety of hydrophobic molecules have been trialed for this purpose, including linear alkyl chains [28][29][30][31][32][33][34], bulky hydrophobic molecules (e.g., cholesterol [35][36][37], pyrene [38,39], cholanic acid [40][41][42], and indocyanine green [43]), and hydrophobic polymers (e.g., ethylene glycol [44,45], polycaprolactone or PCL [46,47], poly(lactic-co-glycolic acid) or PLGA [48], and poly(N-isopropylacrylamide) or pNIPAM [49]. Additionally, HA can be covalently conjugated with metal-chelating functional groups, such as histidine amino acids and chelating agents such as iminodiacetic acid and malonic acid.…”

Section: Fabrication Of Hyaluronic Acid Nanogelsmentioning

confidence: 99%

“…The template is then removed after the crosslinking reaction [53]. Cholesterol [35][36][37] Pyrene [38,39] Cholanic acid [40][41][42] Indocyanine green [43] Ethylene glycol [44,45] Polycaprolactone (PCL) [46,47] Poly(lactic-co-glycolic acid) (PLGA) [48] Poly(N-isopropylacrylamide) (pNIPAM) [1,49,79,80] Chemical crosslinking Amide bond formation with amine linkers using carbodiimide reaction (+) Robust nanogel structure (−) Difficult to control morphology and size of the particles (−) Extra steps to remove excess crosslinkers [5,[52][53][54] Crosslinking of amine-conjugated HA using aldehyde crosslinkers [55,56] Specific crosslinkers for HA [57,58] Self-crosslinking Disulfide formation (+) Simple fabrication (+) Redox-responsiveness (for disulfide-formed HA nanogels) [31,[59][60][61][62][63][64][65] Self-crosslinking of methacrylated HA [66][67][68][69][70] Photocrosslinking of methacrylated HA or tetrazole-modified HA 73-77 [73][74][75]…”

Section: Fabrication Of Hyaluronic Acid Nanogelsmentioning

confidence: 99%

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Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

Myint,

Laomeephol,

Thamnium

et al. 2023

Pharmaceutics

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Hyaluronic acid (HA) nanogels are a versatile class of nanomaterials with specific properties, such as biocompatibility, hygroscopicity, and biodegradability. HA nanogels exhibit excellent colloidal stability and high encapsulation capacity, making them promising tools for a wide range of biomedical applications. HA nanogels can be fabricated using various methods, including polyelectrolyte complexation, self-assembly, and chemical crosslinking. The fabrication parameters can be tailored to control the physicochemical properties of HA nanogels, such as size, shape, surface charge, and porosity, enabling the rational design of HA nanogels for specific applications. Stimulus-responsive nanogels are a type of HA nanogels that can respond to external stimuli, such as pH, temperature, enzyme, and redox potential. This property allows the controlled release of encapsulated therapeutic agents in response to specific physiological conditions. HA nanogels can be engineered to encapsulate a variety of therapeutic agents, such as conventional drugs, genes, and proteins. They can then be delivered to target tissues with high efficiency. HA nanogels are still under development, but they have the potential to become powerful tools for a wide range of theranostic or solely therapeutic applications, including anticancer therapy, gene therapy, drug delivery, and bioimaging.

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Section: Fabrication Of Hyaluronic Acid Nanogelsmentioning

confidence: 99%

Section: Fabrication Of Hyaluronic Acid Nanogelsmentioning

confidence: 99%

Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

Myint,

Laomeephol,

Thamnium

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

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Synthetic Cells from Droplet‐Based Microfluidics for Biosensing and Biomedical Applications

Ngocho,

Yang,

Wang

et al. 2024

Small

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Synthetic cells function as biological mimics of natural cells by mimicking salient features of cells such as metabolism, response to stimuli, gene expression, direct metabolism, and high stability. Droplet‐based microfluidic technology presents the opportunity for encapsulating biological functional components in uni‐lamellar liposome or polymer droplets. Verified by its success in the fabrication of synthetic cells, microfluidic technology is widely replacing conventional labor‐intensive, expensive, and sophisticated techniques justified by its ability to miniaturize and perform batch production operations. In this review, an overview of recent research on the preparation of synthetic cells through droplet‐based microfluidics is provided. Different synthetic cells including lipid vesicles (liposome), polymer vesicles (polymersome), coacervate microdroplets, and colloidosomes, are systematically discussed. Efforts are then made to discuss the design of a variety of microfluidic chips for synthetic cell preparation since the combination of microfluidics with bottom–up synthetic biology allows for reproductive and tunable construction of batches of synthetic cell models from simple structures to higher hierarchical structures. The recent advances aimed at exploiting them in biosensors and other biomedical applications are then discussed. Finally, some perspectives on the challenges and future developments of synthetic cell research with microfluidics for biomimetic science and biomedical applications are provided.

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Synthesis and physicochemical properties of doxorubicin-loaded PEGA containing amphiphilic block polymeric micelles

Panda,

Hsieh,

Shen

et al. 2024

J Polym Res

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Preparation of polymersomes from synthesized hyaluronic acid-graft-poly(ε-caprolactone) copolymers for drug delivery to the brain

Cited by 8 publications

References 66 publications

Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

Synthetic Cells from Droplet‐Based Microfluidics for Biosensing and Biomedical Applications

Synthesis and physicochemical properties of doxorubicin-loaded PEGA containing amphiphilic block polymeric micelles

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